RESEARCH

Research Units

Nano-medicine and Drug Delivery System

Introduction of gene or drug into cells has been used for a wide range of medical applications. We are studying the use of physical delivery of drug or reprogramming factors into the cells and tissue, as a safe and reliable method. We are also exploring integrated diagnostic and therapeutic (theranostics) modalities/nanoparticles/agents, as a unique approach in nanomedicine.

Physical deliveries are based on applying electrical/mechanical stresses to the cells. In this respect, attention has been made to understand biophysical reactions to reversibly manipulate the cells by the external stress. We have been investigating promising physical delivery methods including: electroporation with nanosecond pulsed electric fields, needle-free painless microinjection, micro/nano-particle carrier laser-biolistic delivery, sonoporation with microfluidics, and shock waves; which are shown to be appropriate for clinical applications.

Nano-medicine and Drug Delivery System

Unit members

  • Japan
    Unit coordinator
    Hamid HOSANO Website
    Professor, Bioelectrics Department, Institute of Pulsed Power Science, Kumamoto University
    Japan
  • Japan
    Nushin HOSANO
    Visiting Asscociate Professor, Bioelectrics Department, Institute of Pulsed Power Science, Kumamoto University
    Japan
  • USA
    Hamid GHANDEHARI Website
    Professor, Director of Utah Center for Nanomedicine; Professor of Department of Pharmaceutics and Pharmaceutical Chemistry and Bioengineering, University of Utah
    USA
  • USA
    Amir A. FARAJIAN Website
    Associate Professor, Department of Mechanical and Materials Engineering, Wright State University
    USA
  • India
    Viren Ivor MENEZES Website
    Professor, Department of Aerospace Engineering, Indian Institute of Technology Bombay
    India
  • UK
    Konstantinos KONTIS Website
    Distinguished Professor, IROAST, Kumamoto University/ Professor, School of Engineering, University of Glasgow
    UK
  • Australia
    Firuz ZARE Website
    Professor, Power and Energy Group, The University of Queensland
    Australia
  • Japan
    Unit coordinator
    Takuro NIIDOME Website
    Professor, Faculty of Advanced Science and Technology, Kumamoto University
    Japan
  • USA/ Republic of Korea
    Ick Chan KWON Website
    Presidential Scholar, Dana Faber Cancer Center, Harvard Medical School/ Principal Research Scientist, Biomedical Research Institute, Korea Institute of Science and Technology (KIST)
    USA/ Republic of Korea
  • Japan
    Ruda Lee Website
    Associate Professor, International Research Organization for Advanced Science and Technology (IROAST), Kumamoto University
    Japan
  • Japan
    Keiichi MOTOYAMA Website
    Associate Professor, Graduate School of Pharmaceutical Sciences, Kumamoto University
    Japan
  • Japan
    Taishi HIGASHI Website
    Associate Professor, Priority Organization for Innovation and Excellence, Kumamoto University
    Japan