RESEARCH

Research Clusters

Nano-medicine and Drug Delivery System

Introduction of gene or drug into cells has been used for a wide range of medical applications. We are studying the use of physical delivery of drug or reprogramming factors into the cells and tissue, as a safe and reliable method. We are also exploring integrated diagnostic and therapeutic (theranostics) modalities/nanoparticles/agents, as a unique approach in nanomedicine.

Physical deliveries are based on applying electrical/mechanical stresses to the cells. In this respect, attention has been made to understand biophysical reactions to reversibly manipulate the cells by the external stress. We have been investigating promising physical delivery methods including: electroporation with nanosecond pulsed electric fields, needle-free painless microinjection, micro/nano-particle carrier laser-biolistic delivery, sonoporation with microfluidics, and shock waves; which are shown to be appropriate for clinical applications.

Nano-medicine and Drug Delivery System

Unit members

  • Japan
    Unit coordinator
    Hamid HOSANO Website
    Professor, Institute of Industrial Nanomaterials, Kumamoto University
    Japan
  • Japan
    Nushin HOSANO
    Visiting Asscociate Professor, Institute of Industrial Nanomaterials, Kumamoto University
    Japan
  • USA
    Hamid GHANDEHARI Website
    Professor, Director of Utah Center for Nanomedicine; Professor of Department of Pharmaceutics and Pharmaceutical Chemistry and Bioengineering, University of Utah
    USA
  • USA
    Amir A. FARAJIAN Website
    Professor, Department of Mechanical and Materials Engineering, Wright State University
    USA
  • India
    Viren Ivor MENEZES Website
    Professor, Department of Aerospace Engineering, Indian Institute of Technology Bombay
    India
  • UK
    Konstantinos KONTIS Website
    Distinguished Professor, IROAST, Kumamoto University/ Professor, School of Engineering, University of Glasgow
    UK
  • Australia
    Firuz ZARE Website
    Professor, Power and Energy Group, The University of Queensland
    Australia

Achievements

Publications

M. Thorat, S. Sahu, V. Menezes, A. Gokhale, H. Hosano, Shock loading of closed cell aluminum foams in the presence of an air cavity, Applied Sciences, 10(12), 4128, June 2020 DOI: 10.3390/app10124128

F. Zare, N. Ghasemi, N. Bansal, G. Abhishek, H. Hosano, Increasing the production yield of white oyster mushrooms with pulsed electric fields, IEEE Trans. Plasma Science, 49(2), 805-812, February 2021
DOI: 10.1109/TPS.2021.3053071

M. Sato, T. Sakugawa, T. Yamashita, N. Hosano, H. Hosano, Effects of Voltage and Current Waveforms on Pulse Discharge Energy Transfer to Underwater Shock Waves for Medical Applications, IEEE Trans. Plasma Science, 48(7): 2639-2645, July 2020
DOI: 10.1109/TPS.2020.2992638

Z. Yang ; H. Cao ; J. Hao ; H. Hosano ; S. Katsuki ; H. Akiyama ; C. Zhang, Post-breakdown dielectric recovery characteristics of water for high-repetition-rate switch, IEEE Transactions on Dielectrics and Electrical Insulation 27(3):909-914, June 2020
DOI: 10.1109/TDEI.2020.008507

Grants

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