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RESEARCH

Research Units

Development of Novel Therapeutic Strategy Using Iron Targeted Upconversion Nanoparticles for Parkinson's Disease

My research team focuses on the development and evaluation of nanomaterials to overcome biological barriers for efficient drug delivery. It consists of a nano scientist, biologist, veterinarian and medical doctor from the universities in the Republic of Korea, Japan, and Australia.

 

Development of Novel Therapeutic Strategy Using Iron Targeted Upconversion Nanoparticles for Parkinson's Disease

Unit members

  • Japan
    Unit coordinator
    Ruda LEE Website
    Associate Professor, Institute of Industrial Nanomaterials(IIna), Kumamoto University
    Japan
  • Republic of Korea
    Yong II PARK
    Associate Professor, Chonnam National University
    Republic of Korea
  • Republic of Korea
    Jung Hoon CHOI
    Professor, Kangwon National University
    Republic of Korea
  • Australia
    Xiaoxue XU
    Chancellor Postdoctoral Research Fellow, University of Technology Sydney
    Australia

Achievements

Publications

Ruda Lee

  • Chinmaya Mahapatra, Ruda Lee, Manash K. Paul. Emerging role and promise of nanomaterials in organoid research. Drug Discovery Today, 27, 890-899. March 2022.
  • Kang Pa Lee, Suji Baek, Myeong Sik Yoon, Ji Soo Park, Bok Sil Hong, Sang Ju Lee, Seung Jun Oh, Seung Hae Kwon, Ruda Lee, Dae Ho Lee, Kang-Seo Park, Byung Seok Moon. Potential anticancer effect of aspirin and 2'‑hydroxy‑2,3,5'‑trimethoxychalcone‑linked polymeric micelles against cervical cancer through apoptosis. Oncology Letters, 23, 31, November 2021.
  • Sajid Fazal, Ruda Lee*. Biomimetic Bacterial Membrane Vesicles for Drug Delivery Applications. Pharmaceutics, 13, 1430. September 2021.
  • Yong Il Park, Seung-Hae Kwon, Gibok Lee, Keiichi Motoyama, Min Woo Kim, Min Lin, Takuro Niidome, Jung Hoon Choi, Ruda Lee*. pH-sensitive multi-drug liposomes targeting folate receptor β for efficient treatment of non-small cell lung cancer.Journal of Controlled Release, 330, 1-14, February 2021.
  • Sho Ueno, Min Woo Kim, Gibok Lee, Yong Il Park, Takuro Niidome, and Ruda Lee*. Development of ErbB2-Targeting Liposomes for Enhancing Drug Delivery to ErbB2-Positive Breast Cancer. Pharmaceutics, 12, 585, June 2020.
  • Xiaoxue Xu, Hongxu Lu and Ruda Lee. Near Infrared Light Triggered Photo/Immuno-Therapy Toward Cancers. Frontiers in Bioengineering and Biotechnology, 8, 488, 2020.
  • Song Yeul Lee*, Ruda Lee*, Eunha Kim, Sanghee Lee and Yong Il Park. Near-Infrared Light-Triggered Photodynamic Therapy and Apoptosis Using Upconversion Nanoparticles with Dual Photosensitizers. Frontiers in Bioengineering and Biotechnology, 8, 275. Apr 2020.

Yong Il PARK

  • Song Yeul Lee, Joo-Yeon Park, Hyun-Jae Kim, Yun-Sung Lee, Yong Il Park*. Prussian Blue-Graphene Oxide Composite Cathode for a Sodium-Ion Capacitor with Improved Cyclic Stability and Energy Density. Journal of Alloys and Compounds, 898, 162952, March 2022.
  • Song Yeul Lee, Dasom Park, Byung Sun Yoon, Yun-Sung Lee,* Yong Il Park,* Chang Hyun Ko*. Atomic Layer Deposition-Based Synthesis of TiO2 and Al2O3 Thin-Film Coatings on Nanoparticle Powders for Sodium-Ion Batteries with Enhanced Cyclic Stability. Journal of Alloys and Compounds, 897, 163113, March 2022.
  • Naresh, Venkata N. K. B. Adusumalli, Yong Il Park, Nohyun Lee. NIR Triggered NaYF4:Yb,Tm@NaYF4/CsPb(Br1-x/Ix)3 Composite for Up-converted White Light Emission and Dual-Model Anti-counterfeiting Applications. Materials Today Chemistry, 23, 100752, March 2022.
  • Ranjith Thangavel, Daseul Han, Brindha Moorthy, Bala Krishnan Ganesan, Megala Moorthy, Yong Il Park, Kyung-Wan Nam, Yun-Sung Lee. Understanding the Structural Phase Transitions in Na3V2(PO4)3 Symmetrical Sodium-Ion Batteries Using Synchrotron-Based X-Ray Techniques. Small Methods, 6, 2100888, February 2022.
  • Ramesh Poonchi Sivasankaran, Pran Krisna Das, Maheswari Arunachalam, Rohini Subhash Kanase, Yong Il Park, Jeongsuk Seo, Soon Hyung Kang. TiO2 Nanotube Arrays Decorated with Reduced Graphene Oxide and Cu-Tetracyanoquinodimethane as Anode Materials for Photoelectrochemical Water Oxidation. ACS Applied Nano Materials, 4, 13218-13233, December 2021.
  • Yong Il Park, Seung-Hae Kwon, Gibok Lee, Keiichi Motoyama, Minwoo Kim, Min Lin, Takuro Niidome, Jung Hoon Choi, Ruda Lee. pH-Sensitive Multi-Drug Liposomes Targeting Folate Receptor β for Efficient Treatment of Non-Small Cell Lung Cancer. Journal of Controlled Release, 330, 1-14, Feb 2021.
  • Da Hwi Gu, Jungsoo Lee, Hyeong Woo Ban, Gibok Lee, Minju Song, Wooyong Choi, Seongheon Baek, Hyewon Jeong, Song Yeul Lee, Yonghoon Choi, Jongnam Park, Yong Il Park,* Jae Sung Son*. Colloidal Suprastructures Self-Organized from Oppositely Charged All-Inorganic Nanoparticles. Chemistry of Materials, 32, 8662-8671, Oct 2020.
  • Sho Ueno, Min Woo Kim, Gibok Lee, Yong Il Park, Takuro Niidome, Ruda Lee. Development of ErbB2-Targeting Liposomes for Enhancing Drug Delivery to ErbB2-Positive Breast Cancer. Pharmaceutics, 12, 585, Aug 2020.
  • Jinyue Zhang, Mingshi Jin, Yong Il Park, Longyi Jin, Bo Quan. Facile Synthesis of Ultra-Small Hollow Manganese Silicate Nanoparticles as pH/GSH-Responsive T1-MRI Contrast Agents. Ceramics International, 46, 18632–18638, Jun 2020.
  • Song Yeul Lee, Ruda Lee, Eunha Kim, Sanghee Lee,* Yong Il Park*. Near-Infrared Light-Triggered Photodynamic Therapy and Apoptosis using Upconversion Nanoparticles with Dual Photosensitizers. Frontiers in Bioengineering and Biotechnology, 8, 275, Apr 2020.
  • Song Yeul Lee, Gibok Lee, Young-Si Jun, Yong Il Park*. Visible/Near-Infrared Driven Highly Efficient Photocatalyst Based on Upconversion Nanoparticles/g-C3N4 Applied Surface Science, 508, 144839, Apr 2020.

Jung Hoon CHOI

  • Jung HY, Kim W, Hahn KR, Kang MS, Kwon HJ, Choi JH, Yoon YS, Kim DW, Yoo DY, Won MH, Hwang IK. Changes in the expression of the B subunit of vacuolar H+-ATPase, in the hippocampus, following transient forebrain ischemia in gerbils. Iran J Basic Med Sci. 2021 Nov;24(11):1482-1487.
  • Jung HY, Kim W, Hahn KR, Nam SM, Yi SS, Kwon HJ, Kang MS, Choi JH, Kim DW, Yoon YS, Hwang IK. Spatial and temporal changes in the PGE2 EP2 receptor in mice hippocampi during postnatal development and its relationship with cyclooxygenase-2. Iran J Basic Med Sci. 2021 Jul;24(7):908-913. doi: 10.22038/ijbms.2021.56286.12556.
  • Yong Il Park, Seung-Hae Kwon, Gibok Lee, Keiichi Motoyama, Min Woo Kim, Min Lin, Takuro Niidome, Jung Hoon Choi, Ruda Lee. pH-sensitive multi-drug liposomes targeting folate receptor β for efficient treatment of non-small cell lung cancer. Journal of Controlled Release, 330, 1-14, February 2021.
  • Yoon-Hwan Kim, Min Soo Kang, Tae Hyeong Kim, Yunho Jeong, Jin-Ok Ahn, Jung Hoon Choi*, Jin-Young Chung. Anti-Inflammatory and Immune Modulatory Effects of Synbio-Glucan in an Atopic Dermatitis Mouse Model Nutrients. 2021 Apr; 13(4): 1090.
  • Yoon-Hwan Kim, Tae Hyeong Kim, Min Soo Kang, Jin-Ok Ahn, Jung Hoon Choi*, Jin-Young Chung. Comparison of the presentation of atopic dermatitis induced by trinitrochlorobenzene and house dust mite in NC/Nga mice J Vet Sci. 2020 Jul; 21(4): e59.
  • Sumin Yun, Woosuk Kim, Min Soo Kang, Tae Hyeong Kim, Yoonhwan Kim, Jin-Ok Ahn, Jung Hoon Choi, In Koo Hwang, Jin-Young Chung. Neuropathological changes in dorsal root ganglia induced by pyridoxine in dogs. BMC Neurosci. 2020; 21: 11.

Xiaoxue XU

  • B Hu, G Bao, X Xu, K Yang, The Topical Hemostatic Materials for Coagulopathy, Journal of Materials Chemistry B, 2022, 10, 1946-1959
  • Z Deng, L Zhao, H Zhou, X Xu, W Zheng, Recent advances in electrochemical analysis of hydrogen peroxide towards in vivo detection, Process Biochem., 2022, 115, 57-69
  • G Bao, K Wang, L Yang, J He, B He*, X Xu*, Y Zheng*, Feasibility evaluation of a Zn-Cu alloy for intrauterine devices: in vitro and in vivo studies, Acta Biomater., 2022, https://doi.org/10.1016/j.actbio.2022.01
  • Gao, S. Li, X. Xu, C. Zou, G. Zhang, Highly Sensitive H2 Sensors Based on Co3O4/PEI-CNTs at Room Temperature, J. Nanomater., 2022, https://doi.org/10.1155/2022/4743040
  • Zhang, X. Zhang, Z. Li, R. Yi, Z. Li, N. Wang, X. Xu, Z. Azimi, L. Li, M. Lysevych, X. Gan, Y. Lu, H. Tan, C. Jagadish, L. Fu, A New Strategy for Selective Area Growth of Highly Uniform InGaAs/InP Multiple Quantum Well Nanowire Arrays for Optoelectronic Device Applications, Adv. Funct. Mater., 2021, 32 (3), 2103057
  • Holmes, S. Chambon, A. Holmes, X. Xu, K. Hirakawa, E. Deniau, C. Lartigau-Dagron, A. Bousquet, Organic semiconductor colloids: From the knowledge acquired in photovoltaics to the generation of solar hydrogen fuel, Curr. Opin. Colloid Interface Sci., 2021, 56, 101511
  • Wang, G. Bao, Q. Fan, L. Zhu, L. Yang, T. Liu, Z. Zhang, G. Li, X. Chen, X. Xu*, B. He*, Y. Zheng*, In vitro and in vivo studies of Cu-38Zn alloy to evaluate its the feasibility as a material for intrauterine devices, Acta Biomater., 2021, 138, 561-575
  • Xu, Z. Jia, Y. Zheng, Y., Wang, Bioadaptability of biomaterials: Aiming at precision medicine, Matter, 2021, 4, 2648-2650
  • Liu, H. Li, Y. Li, X. Xu, Z. Yang, G. Ding, Optimization of the Discrete Structure in a Pressure Sensor Based on a Multiple-Contact Mechanism to Improve Sensitivity and Nonlinearity, IEEE Sens. J., 2021, 21, 21259 - 21267
  • Fan, G. Bao, D. Ge, K. Wang, M. Sun, T. Liu, J. Liu, Z. Zhang, X. Xu, X. Xu*, B. He*, J. Rao, Y. Zheng*, Effective Easing of the Side Effects of Copper Intrauterine Devices using Ultra-fine-grained Cu-0.4Mg Alloy, Acta Biomater., 2021,128, 523-539
  • Wen, X. Xu, S. Cheong, S. Lo, J. Chen, S. Chang, C. Dwyer, Metrology of convex-shaped nanoparticles via soft classification machine learning of TEM images, Nanoscale Adv., 2021, 3, 6956-6964
  • Deming Liu, Xiaoxue Xu, Yi Du, Jiayan Liao, Shihui Wen, Xiaotong Dong, Yan Jin, Lei Liu, Dayong Jin, John A. Capobianco, Dezhen Shen. Reconstructing the Surface Structure of NaREF4 Upconversion Nanocrystals with a Novel K+ Treatment. Mater.2021, 33, 7, 2548–2556 March 2021.
  • Yongliang Chen, Xiaoxue Xu, Chi Li, Avi Bendavid, Mika Westerhausen, Carlo Bradac, Milos Toth, Igor Aharonovich, Toan Trong Tran. Bottom‐Up Synthesis of Hexagonal Boron Nitride Nanoparticles with Intensity‐Stabilized Quantum Emitters. Small. In press March 2021.
  • Hongfang Li, Yahui Li, Kai Wang, Liyan Lai, Xiaoxue Xu, Bin Sun, Zhuoqing Yang, Guifu Ding. Ultra-high sensitive micro-chemo-mechanical hydrogen sensor integrated by palladium-based driver and high-performance piezoresistor. International Journal of Hydrogen Energy. 2021, 46, 1, 1434-1445. January 2021.
  • ZX Deng, JW Tao, W Zhang, HJ Mu, HJ Wu, YB Wang, XX Xu, W Zheng. Effect of protein adsorption on electrospun hemoglobin/gelatin-MWCNTs microbelts modified electrode: Toward electrochemical measurement of hydrogen peroxide. 2021, 257, 123827. January 2021.
  • Guohua Jia and Bing-Jie Ni Derek Hao, Chuangwei Liu, Xiaoxue Xu, mehran kianinia, Igor Aharonovich, Xiaojuan Bai, Xiaoqing Liu, Zhijie Chen, Wei Wei. Surface defect-abundant one-dimensional graphitic carbon nitride nanorods boost photocatalytic nitrogen fixation. New J. Chem., 2020, 44, 20651-20658. November 2020.
  • Sarah Meyer, Raquel Gonzalez de Vega, Xiaoxue Xu, Ziqing Du, Philip A Doble, David Clases. Characterization of Upconversion Nanoparticles by Single-Particle ICP-MS Employing a Quadrupole Mass Filter with Increased Bandpass. Analytical chemistry 2020, 92, 22, 15007-15016. November 2020.
  • Christian Clarke, Mandeep Singh, Sherif Abdulkader Tawfik, Xiaoxue Xu, Michelle JS Spencer, Rajesh Ramanathan, Philipp Reineck, Vipul Bansal, Cuong Ton-That. Mono-to few-layer non-van der Waals 2D lanthanide-doped NaYF4 nanosheets with upconversion luminescence. 2D Materials 2020, 8, 1, 015005. October 2020.
  • Laixu Gao, Xuchen Shan, Xiaoxue Xu, Yongtao Liu, Baolei Liu, Sonquan Li, Chenshuo Ma, Dayong Jin, Fan Wang. Video-rate upconversion display from optimized lanthanide ion doped upconversion nanoparticles. Nanoscale, 2020,12, 18595-18599. June 2020.
  • ZX Deng, JW Tao, LJ Zhao, W Zhang, YB Wang, HJ Mu, HJ Wu, XX Xu, W Zheng. Effect of protein adsorption on bioelectrochemistry of electrospun core-shell MWCNTs/gelatin-Hb nanobelts on electrode surface. Process Biochemistry, 2020, 96, 73-79. June 2020.
  • Ziqing Du, Abhishek Gupta, Christian Clarke, Matt Cappadona, David Clases, Deming Liu, Zhuoqing Yang, Shawan Karan, William S Price, Xiaoxue Xu*. Porous upconversion nanostructures as bimodal biomedical imaging contrast agents. The Journal of Physical Chemistry C 124 (22), 12168-12174. May 2020.
Grants

Ruda LEE

  • CRDF Global female young researcher grant, Granted (Principal Investigator)
  • FY2022 JSPS, Grant-in-Aid for Scientific Research (C), Applied/Granted (Principal Investigator)

Yong Il PARK

  • Korea Basic Science Institute, 2021 Research Facility Council Development Support Project, 2021.04.01~2021.11.30 (Principal Investigator)
  • National Research Foundation of Korea (NRF), Basic Science Research Program, Applied 2021.06.01~2026.05.31 (Principal Investigator)
  • National Research Foundation of Korea (NRF), Basic Science Research Program, 2020.06.01~2021.05.31 (Principal Investigator)
  • National Research Foundation of Korea (NRF), Korea Research Fellowship (KRF) for Postdoctoral Researchers, 2020.08.01~2022.12.31 (Principal Investigator)
  • Korea Basic Science Institute, 2021 Research Facility Council Development Support Project, 2021.04.01~2021.11.30 (Principal Investigator)

Jung Hoon CHOI

  • National Research Foundation of Korea funded by the Ministry of Education (NRF-2019R1I1A3A01061857) (Principal Investigator)

Helen XU

  • Innovative Grant funded by Juvenile Diabetes Research Foundation (USA) (1-INO-2020-914-A) (Principal Investigator)

Activities

[Presentations]

Ruda LEE

  • Ueno Sho, Takuro Niidome, Ruda Lee. Development of ErB2-targeting Liposomes for Enhancing Delivery to ErbB2- positive Breast cancer. The 15th International Student Conference on Advanced Science and Technology(ICAST 2020 Kumamoto, Dec 3-4 (2020), Kumamoto, Japan (Online)
  • Seung-Hae Kwon, Ji Hoon Kim, Jung Hoon Choi, Ruda Lee. Non-invasive early detection of calpain 2-enriched non-small cell lung cancer using a human serum albumin-based calpain-2 nanosensor. 7th International Conference on Bio-Sensing Technology, Busan, Korea (Online)

Yong Il PARK

  • Song Yeul Lee, Yoongu Lim, Dohun Kim, Uk Sim, Yong Il Park. The Effect of NaYF4 Upconversion Nanoparticles for the Enhancement of ZnFe2O4/TiO2 Photoanode, KIChE Fall Meeting and International Symposium, Oct 14-16, Korea (Online).
  • Song Yeul Lee, Yong Il Park. Enhanced Cyclic Performance of Sodium-Ion Capacitor via Surface Modification, 2020 KSIEC Annual Meeting in Celebration of the 30th Anniversary, Oct 28-30, Gwangju, Korea.
  • Yoongu Lim, Song Yeul Lee, Dohun Kim, Uk Sim, Yong Il Park. Enhancement of ZnFe2O4/TiO2 Photoanode Through the Effect of NaYF4 Upconversion Nanoparticles, The 16th International Symposium on Novel and Nano Materials Incorporating the Conference of Korean Powder Metallurgy Institute, Nov 3-6, Jeju, Korea.
  • Panju Kim, Eun Young Lee, Byung Joon Moon, Song Yeul Lee, Yong Il Park, Sang Hyun Lee. Synthesis and Applications of Lead-Free Perovskite Cesium Ytterbium Halide Nanocrystals. The 30th International Photovoltaic Science and Engineering Conference, Nov 9-13 (2020), Jeju, Korea.

Jung Hoon CHOI

  • Yoon-Hwan Kim, Min Soo Kang, Tae Hyeong Kim, Yunho Jeong, Jin-Ok Ahn, Jung Hoon Choi, Jin-Young Chung. Development of Synbio-glucan Functional Spray for Canine Atopic Dermatitis. 2020 KSVS symposium (Korea, Hongchun 19~20 NOV 2020)
  • Min Soo Kang, Woosuk Kim, Tae Hyeong Kim, Hyo Young Jung, Hyun Jung Kwon, Dae Won Kim,In Koo Hwang and Jung Hoon Choi. High fat diet accelerates and exacerbates microgliosis and neuronal damage/death in the somatosensory cortex after transient forebrain ischemia in gerbils. 2020 KALAS International symposium (Korea, Pyeongchang 15~18 Jul 2020)

 

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