Blood vessels change their morphology according to various physiological and pathophysiological conditions. In the field of vascular biology, many biological mechanisms are hypothesized, however, it is very difficult task to quantify the three dimensional vascular architecture.
Our collaboration has already established the image processing method of vascular network (Arima et al., Journal of American Heart Association, 2018). The aim of our team is to establish the unique quantification method of three dimensional data.
Figure: 3D image of murine bone and vascular network in lower leg.
Arima Y, Mukunoki T, et. al., Sample Preparation for Computed Tomography-based Three-dimensional Visualization of Murine Hind-limb Vessels. J Vis Exp. 2021
Grants-in-Aid for Scientific Research-KAKENHI- Challenging research 2022, “CT-based immunostaining”
Yuichiro Arima, “Visualization of blood vessel microstructure by CT ~Efforts of medical-engineering collaboration~”, The 8th International Workshop on X-Ray CT Visualization for Socio-Cultural Engineering and Environmental Materials, 2021.