RESEARCH

Research Units

Nano-medicine and Drug Delivery System

Introduction of gene or drug into cells has been used for a wide range of medical applications. We are studying the use of physical delivery of drug or reprogramming factors into the cells and tissue, as a safe and reliable method. We are also exploring integrated diagnostic and therapeutic (theranostics) modalities/nanoparticles/agents, as a unique approach in nanomedicine.

Physical deliveries are based on applying electrical/mechanical stresses to the cells. In this respect, attention has been made to understand biophysical reactions to reversibly manipulate the cells by the external stress. We have been investigating promising physical delivery methods including: electroporation with nanosecond pulsed electric fields, needle-free painless microinjection, micro/nano-particle carrier laser-biolistic delivery, sonoporation with microfluidics, and shock waves; which are shown to be appropriate for clinical applications.

Nano-medicine and Drug Delivery System

Unit members

  • Japan
    Unit coordinator
    Hamid HOSANO Website

    Professor
    Institute of Industrial Nanomaterials, Kumamoto University

    Japan
  • Japan
    Nushin HOSANO

    Visiting Asscociate Professor
    Institute of Industrial Nanomaterials, Kumamoto University

    Japan
  • UK
    Konstantinos KONTIS Website

    Professor
    School of Engineering, University of Glasgow

    UK
  • Australia
    Firuz ZARE Website

    Professor; Head of School Electrical Engineering and Robotics
    University of Queensland of Technology

    Australia
  • India
    Viren Ivor MENEZES Website

    Professor
    Department of Aerospace Engineering, Indian Institute of Technology Bombay

    India
  • USA
    Hamid GHANDEHARI Website

    Professor/Chair of Department/Director of Utah Center for Nanomedicine
    Department of Molecular Pharmaceutics, University of Utah

    USA
  • USA
    Amir A. FARAJIAN Website

    Professor
    Department of Mechanical and Materials Engineering, Wright State University

    USA

Achievements

Publications

Mona Pakdel*, Zahra Moosavi-Nejad, Rouha Kasra Kermanshahi, Hamid Hosano, Self-assembled uniform keratin nanoparticles as building blocks for nanofibrils and nanolayers derived from industrial feather waste,Journal of Cleaner Production, 335 130331-130331, Feb, 2022, https://doi.org/10.1016/j.jclepro.2021.130331 *Joint publication with Internship student*

Nushin Hosano, Zahra Moosavi-Nejad, Makoto Satoh, Hamid Hosano, Shock Waves Enhance Expression of Glycosphingolipid Tumor Antigen on Renal Cell Carcinoma: Dynamics of Physically Unmasking Hidden Intracellular Markers Independent of Gene-Signaling Pathways, Biomedicines, 10(3) 545-545, Feb, 2022. https://doi.org/10.3390/biomedicines10030545

Tomohiko Yamashita, Reon Yamashita, Hamid Hosano, Takashi Sakugawa, Influence of electrode arrangement on recycling metal-coated plastic (DVD-R) using pulsed electric discharge, Journal of Electrostatics, 110 103557-103557, 2021. https://doi.org/10.1016/j.elstat.2021.103557

M. Thorat, S. Sahu, V. Menezes, A. Gokhale, H. Hosano, Shock loading of closed cell aluminum foams in the presence of an air cavity, Applied Sciences, 10(12), 4128, June 2020 DOI: 10.3390/app10124128

F. Zare*, N. Ghasemi, N. Bansal, G. Abhishek, H. Hosano**, Increasing the production yield of white oyster mushrooms with pulsed electric fields, IEEE Trans. Plasma Science, 49(2), 805-812, February 2021 *Internship student (2019.12.2～2020.1.31) in IROAST Research Internship Program   **Host professor at Kumamoto University
DOI: 10.1109/TPS.2021.3053071

M. Sato, T. Sakugawa, T. Yamashita, N. Hosano, H. Hosano, Effects of Voltage and Current Waveforms on Pulse Discharge Energy Transfer to Underwater Shock Waves for Medical Applications, IEEE Trans. Plasma Science, 48(7): 2639-2645, July 2020
DOI: 10.1109/TPS.2020.2992638

Z. Yang ; H. Cao ; J. Hao ; H. Hosano ; S. Katsuki ; H. Akiyama ; C. Zhang, Post-breakdown dielectric recovery characteristics of water for high-repetition-rate switch, IEEE Transactions on Dielectrics and Electrical Insulation 27(3):909-914, June 2020
DOI: 10.1109/TDEI.2020.008507

Grants

Activities

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