Research Clusters

Nano-medicine and Drug Delivery System

Introduction of gene or drug into cells has been used for a wide range of medical applications. We are studying the use of physical delivery of drug or reprogramming factors into the cells and tissue, as a safe and reliable method. We are also exploring integrated diagnostic and therapeutic (theranostics) modalities/nanoparticles/agents, as a unique approach in nanomedicine.

Physical deliveries are based on applying electrical/mechanical stresses to the cells. In this respect, attention has been made to understand biophysical reactions to reversibly manipulate the cells by the external stress. We have been investigating promising physical delivery methods including: electroporation with nanosecond pulsed electric fields, needle-free painless microinjection, micro/nano-particle carrier laser-biolistic delivery, sonoporation with microfluidics, and shock waves; which are shown to be appropriate for clinical applications.

Nano-medicine and Drug Delivery System

Cluster members

  • Japan
    Hamid HOSANO Website
    Professor, Institute of Industrial Nanomaterials, Kumamoto University
  • Japan
    Nushin HOSANO
    Visiting Asscociate Professor, Institute of Industrial Nanomaterials, Kumamoto University
  • UK
    Konstantinos KONTIS Website
    Professor, School of Engineering, University of Glasgow
  • Australia
    Firuz ZARE Website
    Professor, Power and Energy Group, The University of Queensland
  • India
    Viren Ivor MENEZES Website
    Professor, Department of Aerospace Engineering, Indian Institute of Technology Bombay
  • USA
    Hamid GHANDEHARI Website
    Professor, Director of Utah Center for Nanomedicine; Professor of Department of Pharmaceutics and Pharmaceutical Chemistry and Bioengineering, University of Utah
  • USA
    Amir A. FARAJIAN Website
    Professor, Department of Mechanical and Materials Engineering, Wright State University
  • Netherlands
    Pouyan BOUKANY
    Department of Chemical Engineering, Faculty of Applied Sciences, Delft University of Technology
  • UK
    Stelios RIGOPOULOS
    Department of Mechanical Engineering, Imperial College London



Farzan Zare, Negareh Ghasemi, Nidhi Bansal, Hamid Hosano
Advances in pulsed electric stimuli as a physical method for treating liquid foods
Physics of Life Reviews, 44, 207-266, 2023
DOI: 10.1016/j.plrev.2023.01.007

Md. Mijanur Rahman, Nushin Hosano, Hamid Hosano,
Recovering Microalgal Bioresources: A Review of Cell Disruption Methods and Extraction Technologies
Molecules, 27(9) 2786-2817, 2022



Grants-in-Aid for Scientific Research, Kakenhi (B), 2021-2025



The Carlsberg Foundation “Senior Researcher Award” August 2022 (World Congress on Electroporation), Hamid Hosano

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