Introduction of gene or drug into cells has been used for a wide range of medical applications. We are studying the use of physical delivery of drug or reprogramming factors into the cells and tissue, as a safe and reliable method. We are also exploring integrated diagnostic and therapeutic (theranostics) modalities/nanoparticles/agents, as a unique approach in nanomedicine.
Physical deliveries are based on applying electrical/mechanical stresses to the cells. In this respect, attention has been made to understand biophysical reactions to reversibly manipulate the cells by the external stress. We have been investigating promising physical delivery methods including: electroporation with nanosecond pulsed electric fields, needle-free painless microinjection, micro/nano-particle carrier laser-biolistic delivery, sonoporation with microfluidics, and shock waves; which are shown to be appropriate for clinical applications.
Ziqu Cao, Konstantinos Kontis, Hamid Hosano, Craig White, Ting-Tsung Chang, Muhammed Burak Agir
Vortex Ring Formation Following Shock Wave Diffraction in Low-Pressure Environments Flow,
Turbulence and Combustion, 111(4) 1127-1138, 2023
DOI: https://doi.org/10.1007/s10494-023-00486-3
Md. Mijanur Rahman, Nushin Hosano, Hamid Hosano,
Recovering Microalgal Bioresources: A Review of Cell Disruption Methods and Extraction Technologies
Molecules, 27(9) 2786-2817, 2022
https://doi.org/10.3390/molecules27092786
*Joint International publications resulted from IROAST International Internships:
Farzan Zare*, Negareh Ghasemi, Nidhi Bansal, Hamid Hosano **
*Internship student (2019.12.2-2020.1.31) in IROAST Research Internship Program **Host professor at Kumamoto University
Advances in pulsed electric stimuli as a physical method for treating liquid foods
Physics of Life Reviews, 44, 207-266, 2023
DOI: 10.1016/j.plrev.2023.01.007
Grants-in-Aid for Scientific Research, Kakenhi (B), 2021-2025
The Carlsberg Foundation “Senior Researcher Award” August 2022 (World Congress on Electroporation), Hamid Hosano