RESEARCH

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Development of extrachromosomal DNA control system for reprogramming drug-resistant cancer

Research Keyword: Extrachromosomal DNA, drug resistant cancer

A better understanding of complex and dynamic system is essential to enable us to develop therapeutic strategies that bypass MDR, and also effective ways of inhibiting MDR components to increase the efficacy of our current extensively used chemotherapies. In this research, to get real-time MDR reactive information, we will build optimized, customizable 3D microfluidic chips, set up natural conditions, such as healthy cells and reconstructed 3D tumor microenvironments (TME) use super-resolution imaging devices from a world-class imaging cluster lab.

Development of extrachromosomal DNA control system for reprogramming drug-resistant cancer

Cluster members

  • Japan
    Coordinator
    Ruda LEE Website

    Associate Professor
    Institute of Industrial Nanomaterials(IIna), Kumamoto University

    Japan
  • Korea
    Hoon KIM

    Associate Professor
    School of Pharmacy, Sungkyunkwan University
    ＊IROAST Visiting Professor

    Korea

Achievement

Publications
in press
2023
2022
Publications
Grants
  1. FY2022 JSPS, Grant-in-Aid for Scientific Research (C)
  2. 令和４年度「クロス・フロンティア研究推進事業」, 熊本大学
  3. Brain Pool Korea 2022
  4. FY2023 Kumamoto University Research Achievement Awards
Book publications

Ruda Lee, Yong Il Park. Exosome detection for early cancer diagnosis. Springer, Handbook of Cancer and Immunology, Sep 2023
https://link.springer.com/referenceworkentry/10.1007/978-3-030-80962-1_326-1

 

Activities

Presentations
  1. Ruda Lee, Emerging Role of Nanotechnology for Water Sustainability. Korea International Water Week (KIWW) 2022. 2022/11/24, Daegu, Korea. 
     

    (At the venue)                                                                      (Group photo)

  2. Ruda Lee, Nanoplatform for constructing new approaches to cancer treatment. Kangwon National University, 2022/03/30, Web.

 
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