The mechanical properties of materials are dominated by their microstructures such as grain size, precipitates, phase boundary, grain boundary, etc. In our research group, we aim to clarify the mechanical properties at microscopic level, including tensile properties, fracture and fatigue properties, using the micromechanical testing technology that we have developed. Furthermore, in conjunction with crystal plasticity finite element simulation, we aim to predict the mechanical properties of bulk materials based on those at microscopic scale. The results obtained in this research will contribute for developing toughening design of advanced materials.