Research Clusters

Environmentally Promising Processes for Medical and Skincare Nanomaterials

Research Keyword: biomass based water-solubles, tetrapeptides, hexapeptide, metal/biopolymer nanohybrid materials 

In this research cluster, we would like to propose new processes for producing medically available materials and skincare products with environmentally benign and economically feasible manners. Below are examples of outputs in this project. Throughout this work, we aim to produce materials that have high functionalities and bioactivity.

1) Biomass liquefaction / conversion of thermally-stable organic compounds for recovering;
 (1) bio-active water-solubles
 (2) medically available functional compounds
 (3) cellulose fiber

2) Metal/biopolymer nanohybrid materials preparation

3) Quick and selective degradation of thermally-stable wastewater pollutant compounds.

Cluster members

  • Japan
    Mitsuru SASAKI
    Associate Professor, Division of Biomaterials, Institute of Industrial Nanomaterials (IINa), Kumamoto University
  • France
    Elisabeth BADENS
    Full Professor, CNRS/ Aix Marseille University
  • France
    Olivier BOUTIN
    Professor/IROAST Visiting Professor, CNRS/ Aix Marseille University
  • Japan
    Hamid HOSANO Website
    Professor, Biomaterials and Bioelectrics Division, Institute of Industrial Nanomaterials (IINa), Kumamoto University
  • Canada
    Marleny D.A. SALDAÑA Website
    Professor in Food/Bio-Engineering Processing, Department of Agricultural, Food and Nutritional Sciences, Faculty of Agricultural, Life and Environmental Sciences, University of Alberta
  • UK
    Bushra AL-DURI Website
    Reader in Hydrothermal Processing, School of Chemical Engineering, College of Engineering and Physical Sciences, University of Birmingham
  • Mexico
    Rodolfo MORALES IBARRA Website
    Associate Professor, Faculty of Mechanical and Electrical Engineering Universidad Autonoma de Nuevo Leon
  • Japan
    Cinthya Soreli CASTRO ISSASI
    PhD Candidate, Department of Materials Science and Applied Chemistry, Graduate School of Science and Technology, Kumamoto University
  • Spain
    María José COCERO ALONSO
    Full Professor, Bioeconomy Research Institute, Valladolid University



Masayo Nishizono, Cinthya Soreli Castro Issasi, Jonas Karl Christopher N. Agtaya, Mitsuru Sasaki*, Hiroyuki Mizukami, “Production of dried tomato powder with a high concentration of functional components and nutrients”, Journal of Antioxidant Activity, 2(4), 1-21 (2023).

Mitsuru Sasaki*, Hiras Tumegas Manalu, Ramma Kamogawa, Cinthya Soreli Castro Issasi, Armando T. Quitain, Tetsuya Kida, “Fast and selective production of quercetin and saccharides from rutin using microwave-assisted hydrothermal treatment in the presence of graphene oxide”, Food Chemistry, 405, 134808 (2023). DOI: 10.1016/j.foodchem.2022.134808.

Cinthya Soreli Castro Issasi, Rodolfo Morales Ibarra, and Mitsuru Sasaki*, “In-situ Synthesis of Poly(N-Isopropylacrylamide) Decorated with Silver Nanoparticles Using Pulsed Electrical Discharge in Contact with Water Interface”, Nanocomposites, 8(1), 136-141 (2022). DOI: 10.1080/20550324.2022.2086775


Study on chemical evolution by simulation experiments regarding the plasma processes and hydrothermal conditions with minerals under the Hadean Earth environments, KAKENHI Grant-in-Aid for Scientific Research (B) 2019-2023.

Research on the aging of rice shochu using locally produced wood and its utilization, Project Research at Japan Sake and Syochu Makers Association 2022.



Daigo Murakami, Shoji Hirayama, Yuriko Hoshino, Kazuharu Yamato, Munehiro Hoshino, Mitsuru Sasaki*, “Study on the optimization of subcritical water liquefaction of vinegar residues and acetic acid fermentation conditions for new vinegar products”, #PP-21, Supergreen 2022, Taipei, Taiwan, October 24-29, 2022.

Daigo Murakami, Shoji Hirayama, Yuriko Hoshino, Munehiro Hoshino and Mitsuru Sasaki*, “Recovery of high concentration of amino acids by subcritical water treatment of residuals from vinegar production” APCChE 2022, Kuala Lumpr, Malaysia, August 9-12, 2022.

Natsuko Tashiro and Mitsuru Sasaki*, “Development of novel method for selective conversion of dibutyl phosphate into phospholic acid with the vaporphase pulsed discharges” APCChE 2022, Kuala Lumpr, Malaysia, August 9-12, 2022.

Ryo Yamada and Mitsuru Sasaki*, “Production of chain oligopeptides from diketopiperazine by pulse discharge method” APCChE 2022, Kuala Lumpr, Malaysia, August 9-12, 2022.

Shoji Hirayama, Yuriko Hoshino, Daigo Murakami, Kazuharu Yamato, Takuya Suetsugu, Munehiro Hoshino, and Mitsuru Sasaki*, “Subcritical Water Treatment of Sake Lees and Rice Bran for New Vinegar Production: Product Distribution and Reaction Pathways”, ICAST2022 (online), Kumamoto 2022.

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