RESEARCH

Research Clusters

Nano-medicine and Theranostics

The introduction of genes or drugs into cells has been used for a wide range of medical applications. We are studying the use of physical delivery of drug or reprogramming factors into the cells and tissue, as a safe and reliable method as well as exploring integrated diagnostic and therapeutic (theranostics) modalities/nanoparticles/agents, as a unique approach in nanomedicine.

Nano-medicine and Theranostics

Cluster members

  • Japan
    Coordinator
    Takuro NIIDOME Website

    Professor
    Faculty of Advanced Science and Technology, Kumamoto University

    Japan
  • Republic of Korea
    Ick Chan KWON Website

    Principal Research Scientist
    Biomedical Research Institute, Korea Institute of Science and Technology (KIST)
    ＊IROAST Visiting Professor

    Republic of Korea
  • Japan
    Ruda LEE

    Associate Professor
    Institute of Industrial Nanomaterials (IIna), Kumamoto University

    Japan
  • Japan
    Keiichi MOTOYAMA Website

    Professor
    Faculty of Life Sciences, Kumamoto University

    Japan
  • Japan
    Taishi HIGASHI Website

    Associate Professor
    Priority Organization for Innovation and Excellence, Kumamoto University

    Japan

Achievement

Publications
2024
2023
2022
Publications

* Book publications
Ruda Lee, Yong Il Park. Exosome detection for early cancer diagnosis. Springer Handbook of Cancer and Immunology, Sep 2023

Patents

Ick Chan KWON

  • Ju Hee Ryu, Ick Chan Kwon, KIM Kwangmeyung, Han Young Kim, Eun-Sun Kim. Colon cancer diagnosis or detection composition for predicting response to drug, and composition for preventing or treating colon cancer. US Patent App. 18/041,587 (2024).
  • HoWon J Kim, In-San Kim, Jay S Kim, Sun Hwa Kim, Ick Chan Kwon, Jong Won Lee, Yoo Soo Yang, Hong Yeol Yoon. Therapeutic compounds for red blood cell-mediated delivery of an active pharmaceutical ingredient to a target cell. US Patent 12,006,502 (2024).
  • Yoo Soo Yang, Sun Hwa Kim, Ick Chan Kwon, Eun Hye Kim. Novel peptide-oligonucleotide conjugate and use thereof. US Patent App. 18/551,271 (2024).
  • HoWon J Kim, In-San Kim, Jay S Kim, Sun Hwa Kim, Ick Chan Kwon, Jong Won Lee, Yoo Soo Yang, Hong Yeol Yoon. Therapeutic Compounds for Inhibiting and Reducing the Expression of Cell Surface Proteins. US Patent App. 18/618,258 (2024).
  • HoWon J Kim, In-San Kim, Jay S Kim, Sun Hwa Kim, Ick Chan Kwon, Jong Won Lee, Yoo Soo Yang, Hong Yeol Yoon. Therapeutic Compounds for Red Blood Cell-Mediated Delivery of an Active Pharmaceutical Ingredient to a Target Cell. US Patent 12,139,713 (2024).
Grants

Takuro NIIDOME

  • FY2024 JSPS Grant-in-Aid for Scientific Research (B)
  • AMED Seeds H
  • FY2021 JSPS, Grant-in-Aid for Challenging Research (Exploratory)
  • FY2022 Grant-in-Aid for Scientific Research (B)
  • FY2018 JST, CREST
  • FY2018 AMED

 Ruda LEE

  • FY2023 Kumamoto Researcher Awards
  • FY2022 JSPS, Grant-in-Aid for Scientific Research (C)
  • FY2021 AMED, Infectious Diseases and Immunology Research: U.S.-Japan Cooperative Medical Sciences Program Collaborative Awards
  • Brain Pool Korea 2022

Ick Chan KWON

  • US patent, Ick Chan Kwon, Ju Hee Ryu, Young-ji Ko, Hye-Sun Kim, Nam-Hyuk Cho, Eun-Jeong Yang, Jae Won Lee. Probe for measuring activity of Caspase-1 and composition for diagnosis of inflammatory diseases containing same. 2023
  • US patent, Ick Chan Kwon, Sun Hwa Kim, YANG Yoosoo, Hyosuk Kim. Method for inducing trans-differentiation of cardiomyocytes based on exosome. 2024
  • US patent, HoWon J Kim, In-San Kim, Jay S Kim, Sun Hwa Kim, Ick Chan Kwon, Jong Won Lee, Yoo Soo Yang, Hong Yeol Yoon. Therapeutic Compounds for Red Blood Cell-Mediated Delivery of an Active Pharmaceutical Ingredient to a Target Cell. 2024

Keiichi MOTOYAMA

  • FY2024 JSPS Grant-in-Aid for Scientific Research (B)
  • AMED, Vaccine and New Modality R&D Business
  • FY2021 JSPS Grant-in-Aid for Scientific Research (C)

Taishi HIGASHI

  • FY2024 Grant-in-Aid for Scientific Research (B)
  • PARKS step 2-1
  • Kyutec
  • FY2022 Grant-in-Aid for Scientific Research (B)
  • A-step Ikuseigata
  • The Leading Initiative for Excellent Young Researchers

Activities

[Presentations]

Takuro NIIDOME

  • Takuro Niidome, Anna Kawano, Sayaka Sawada, Tatsuya Baba, Makoto Sasaki, Wei Xu, Graphene Quantum Dots as a Biomaterial: Synthesis and Use of Anti-bacterial and Anti-viral Agents, 44th Annual Meeting of Japanese Society, 2022/11/21, Tokyo, Japan
  • Takuro Niidome, Ryoko Nawata, Emi Takeda, Ryosuke Suzuki, Wei Xu, Preparation of Silver Nanoplates Encapsulated in PLGA Nanoparticles and Control of their Antibacterial Activity by Laser Light, 38th Annual Meeting of the Japanese Society for Drug Delivery System, Online

Ruda LEE

  • Ruda Lee, Emerging Role of Nanotechnology for Water Sustainability. Korea International Water Week (KIWW) 2022. 2022/11/24, Daegu, Korea.

  (Dr. Ruda LEE in the center)                               (Group Photo at the venue)

  • Ruda Lee, Nanoplatform for constructing new approaches to cancer treatment. Kangwon National University, 2022/03/30, Web.

 

Keiichi MOTOYAMA & Taishi HIGASHI

  • Masamichi Inoue, Takashi Saito, Takaomi C. Saido, Risako Onodera, Taishi Higashi, Keiichi Motoyama, Hirofumi Jono, Design and Evaluation of shRNA Polyplex with Cyclodextrin-modified Dendrimer for Treatment of Systemic and Localized Amyloidosis, The 18th International Symposium on Amyloidosis (online), Heidelberg, Germany, September 4-8 (2022).
  • Masamichi Inoue, Takashi Saito, Takaomi C. Saido, Risako Onodera, Taishi Higashi, Keiichi Motoyama, Hirofumi Jono Feasibility Study of Cationic Dendrimer-based Polyplex as a Multi-functional Drug for Alzheimer's Disease, The 3rd International Conference on Advanced Materials and Nanotechnology, Singapore, August 18-19 (2022).
  • Yoshitaka Ohno, Maiko Toshino, Yukio Fujiwara, Yoshihiro Komohara, Risako Onodera, Taishi Higashi, Keiichi Motoyama, Dual-targeting for Colon Cancer Cells and Tumor-Associated Macrophages by Mannose- modified Methyl-β-Cyclodextrins as Antitumor Therapeutic Agents, The 3rd International Conference on Advanced Materials and Nanotechnology, Singapore, August 18-19 (2022).

           
              (Awarded at the conference)                                    (Meal time at Singapore)

 

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