Research Clusters

Nano-medicine and Theranostics

The introduction of genes or drugs into cells has been used for a wide range of medical applications. We are studying the use of physical delivery of drug or reprogramming factors into the cells and tissue, as a safe and reliable method as well as exploring integrated diagnostic and therapeutic (theranostics) modalities/nanoparticles/agents, as a unique approach in nanomedicine.

Nano-medicine and Theranostics

Cluster members

  • Japan
    Takuro NIIDOME Website
    Professor, Faculty of Advanced Science and Technology, Kumamoto University
  • Republic of Korea
    Ick Chan KWON Website
    Principal Research Scientist, Biomedical Research Institute, Korea Institute of Science and Technology (KIST)/ IROAST Visiting Professor
    Republic of Korea
  • Japan
    Ruda LEE
    Associate Professor,Institute of Industrial Nanomaterials (IIna), Kumamoto University
  • Japan
    Keiichi MOTOYAMA Website
    Professor, Faculty of Life Sciences, Kumamoto University
  • Japan
    Taishi HIGASHI Website
    Associate Professor, Priority Organization for Innovation and Excellence, Kumamoto University


  • Ruda Lee, Sho Tanigawa, Yong Il Park, Hoon Kim. Antimetabolite Prodrug Delivery for Non-small Cell Lung Cancer, Korean Society for Biotechnology and Bioengineering Journal, 38: 236-243, 2023

* Book publications
Ruda Lee, Yong Il Park. Exosome detection for early cancer diagnosis. Springer Handbook of Cancer and Immunology, Sep 2023



  1. Waliul Islam, Hiroyasu Tsutsuki, Katsuhiko Ono, Ayaka Harada, Kozo Shinozaki, Takuro Niidome, Jun Fang, Tomohiro Sawa, Structural determination of the nanocomplex of borate with styrene-maleic acid copolymer-conjugated glucosamine used as a multifunctional anticancer drug, ACS Appl. Bio Mater, 12, 5953–5964 (2022)
  2. Waliul Islam, Takuro Niidome, Tomohiro Sawa, The enhanced permeability and retention effect as a ubiquitous and epoch-Making phenomenon in the selective targeting of drugs to solid tumors, Pers. Med., 12, 1964 (2022)
  3. Yuko T Sato, Daisuke Asai, Keiko Terada, Jeong-Hun Kang, Takeshi Mori, Takuro Niidome, Hideki Nakashima, Yoshiki Katayama, A model of transcriptional activation of DNA by loosening of chromatin structure, Lett., 51, 1109–1112 (2022)
  4. Ayaka Harada, Hiroyasu Tsutsuki, Tianli Zhang, Kinnosuke Yahiro, Tomohiro Sawa, Takuro Niidome, Controlled delivery of an anti-inflammatory toxin to macro-phages by mutagenesis and nanoparticle modification, Nanomaterials, 12, 2161 (2022)
  5. Makoto Sasaki, Wei Xu, Yuki Koga, Yuki Okazawa, Akira Wada, Ichiro Shimizu, Takuro Niidome, Effect of parylene C on the corrosion resistance of bioresorbable cardiovascular stents made of magnesium alloy 'Original ZM10', Materials, 15, 3132 (2022)
  6. Mai Shinohara, Wei Xu, Sun-nam Kim, Tuyoshi Fukaminato, Takuro Niidome, Seiji Kurihara, Photo-control of cellular uptake by the selective adsorption of spiropyran derivatives on albumin, Lett., 51, 594–597 (2022)
  7. Wei Xu, Makoto Sasaki, Takuro Niidome, Sirolimus release from biodegradable polymers for coronary stent, Pharmaceutics, 14, 492 (2022)
  8. Emi Takeda, Wei Xu, Mitsuhiro Terakawa, Takuro Niidome, Tailored structure and antibacterial properties of silica-coated silver nanoplates by pulsed laser irradiation, ACS Omega, 7, 7251–7256 (2022)
  9. Mai Shinohara, Yuya Ashikaga, Wei Xu, Sunnam Kim, Tuyoshi Fukaminato, Takuro Niidome, Seiji Kurihara, Photochemical OFF/ON cytotoxicity switching by using a photochromic surfactant with visible light irradiation, ACS Omega, 7, 6093–6098 (2022)

Ruda LEE

  1. Strategic Review of Germany's LULUCF Policy Development Process: Implications for Korea. Woojin Lee Leehyung Kim, Ruda Lee*. Journal of Wetlands Research, 2022, 24, 102-114.

Ick Chan KWON

  1. Improved survival rate and minimal side effects of doxorubicin for lung metastasis using engineered discoidal polymeric particles. Sanghyo Park, Hyungkyu Park, Chaewon Park, Wan Su Yun, Soonjae Hwang, Hong Yeol Yoon, Ick Chan Kwon, Kwangmeyung Kim, Jaehong Key. Biomater, Sci., 2022, 10, 4335-4344.
  2. Ultraefficient extracellular vesicle–guided direct reprogramming of fibroblasts into functional cardiomyocytes. Hyosuk Kim, Byeong-Wook Song, Soon-Jung Park, Seong Woo Choi, Hanbyeol Moon, Ki-Chul Hwang, Sun-Woong Kang, Sung-Hwan Moon, Yoosoo Yang, Ick Chan Kwon*, Sun Hwa Kim. Science Advances, 2022,8, eabj6621.
  3. PDL1-binding peptide/anti-miRNA21 conjugate as a therapeutic modality for PD-L1high tumors and TAMs. Eun Hye Kim, Jongwon Lee, Gijung Kwak, Hochung Jang, Hyosuk Kim, Haeun Cho, Yeongji Jang, Jiwoong Choi, Sung-Gil Chi, Kwangmeyung Kim, Ick Chan Kwon, Yoosoo Yang, Sun Hwa Kim. J. Controlled Release, 2022, 345, 62-74.
  4. Exosome-guided direct reprogramming of tumor-associated macrophages from protumorigenic to antitumorigenic to fight cancer. Hyosuk Kim, Hyun-Ju Park, Hyo Won Chang, Ji Hyun Back, Su Jin Lee, Yae Eun Park, Eun Hye Kim, Yeonsun Hong, Gijung Kwak, Ick Chan Kwon, Ji Eun Lee, Yoon Se Lee, Sang Yoon Kim, Yoosoo Yang, Sun Hwa Kim. Bioactive Materials, 2023, 25, 527-540.
  5. Molecularly engineered siRNA conjugates for tumor-targeted RNAi therapy. Jong Won Lee, Jiwon Choi, Yeonho Choi, Kwangmeyung Kim, Yoosoo Yang, Sun Hwa Kim, Hong Yeol Yoon, Ick Chan Kwon*. J. Controlled Release, 2022, 351, 713-726.
  6. Intracellular Glucose‐Depriving Polymer Micelles for Anti‐Glycolytic Cancer Treatment. Jangwook Lee, Kwangmeyung Kim, Ick Chan Kwon, Kuen Yong Lee. Advanced materials, 2022, 35, 2207342.


  1. Ohno, M. Toshino, A. F. A. Mohammed, Y. Fujiwara, Y. Komohara, R. Onodera, T. Higashi, K. Motoyama. Mannose-methyl-b-cyclodextrin suppresses tumor growth of colon cancer by targeting tumor-associated macrophages. Carbohydr. Polym., 305, 120551 (2023).
  2. A. Sakai, Y. Yamashita, S. Misumi, N. Kishimoto, R. Onodera, T. Higashi, H. Arima, K. Motoyama, Nanoparticle composites of folic acid-modified methyl-b-cyclodextrin and adamantane/human serum albumin for enhanced antitumor activity. FEBS Open Bio, 13, 233-245 (2023).
  3. A. F. A. Mohammed, M. H. Othman, T. Taharabaru, K. M. Elamin, K. Ito, M. Inoue, M. El-Badry, K. I. Saleh, R. Onodera, K. Motoyama, T. Higashi, Stabilization and movable ligand-modification by folate-appended polyrotaxanes for systemic delivery of siRNA polyplex. ACS Macro. Lett., 11, 1225-1229 (2022).
  4. T. Hayashi, F. Nakagawa, Y. Ohno, Y. Suzuki, H. Ishiki, R. Onodera, T. Higashi, Y. Shimamura, H. Itou, Y. Iwase, H. Arima, K. Motoyama, Antigen stabilizing hydrogels based on cyclodextrins and polyethylene glycol act as type-2 adjuvants with suppressed local irritation. Eur. J. Pharm. Biopharm., 181, 113-121 (2022).
  5. Y. Yamada, T. Miwa, M, Nakashima, A, Shirakawa, N. Namba, Y. Kondo, T. Takeo, N. Nakagata, K. Motoyama, T. Higashi, H. Arima, Y. Kurauchi, T. Seki, H. Katsuki, Y. Okada, A. Ichikawa, K. Higaki, K. Hayashi, K. Minami, N. Yoshikawa, R. Ikeda, Y. Ishikawa, T. Kajii, K. Tachii, H. Takeda, Y. Orita, M. Matsuo, T. Irie, Y. Ishitsuka, Fine-tuned cholesterol solubilizer, mono-6-O-a-D-maltosyl-g-cyclodextrin, ameliorates experimental Niemann-Pick disease type C without hearing loss. Biomed. Pharmacother., 155, 113698 (2022).
  6. M. Inoue, T. Higashi, Y. Hayash, R. Onodera, K. Fujisawa, T. Taharabaru, R. Yokoyama, K. Ouchi, Y. Misumi, M. Ueda, Y. Inoue, M. Mizuguchi, T. Saito, T. Saido, Y. Ando, H. Arima, K. Motoyama, H. Jono, Multifunctional therapeutic cyclodextrin-appended dendrimer complex for treatment of systemic and localized amyloidosis. ACS Appl. Mater. Interfaces, 14, 40599-40611 (2022).
  7. M. Inoue, K. Muta, A. F. A. Mohammed, R. Onodera, T. Higashi, K. Ouchi, M. Ueda, Y. Ando, H. Arima, H. Jono, K. Motoyama, Feasibility study of Dendrimer-based TTR-CRISPR pDNA polyplex for ocular amyloidosis in vitro. Biol. Pharm. Bull., 45, 1660-1668 (2022).
  8. F. Nakagawa, Y. Shimamura, Y. Suzuki, T. Taharabaru, H. Itou, Y. Iwase, R. Onodera, T. Higashi, K. Motoyama, Application of cyclodextrin/polyethylene glycol in blood-storage tools for liquid biopsy. Mater. Lett., 324, 132660 (2022).
  9. Y. Nakatani, Z. Ye, Y. Ishizue, T. Higashi, T. Imai, I. Fujii, M. Michigami, A 'human and mouse cross-reactive' albumin-binding helix-loop-helix peptide tag for prolonged bioactivity of therapeutic proteins. Mol. Pharm., 19, 2279-2286 (2022).
  10. T. Nishida, R. Yokoyama, Y. Kubohira, Y. Maeda, T. Takeo, N. Nakagata, H. Takagi, K. Ishikura, K. Yanagihara, S. Misumi, N. Kishimoto, Y. Ishitsuka, Y. Kondo, T. Irie, M. Soga, T. Era, R. Onodera, T. Higashi, K. Motoyama, Lactose-appended hydroxypropyl-b-cyclodextrin ameliorates hepatosplenomegaly in Niemann-Pick Type C Disease by lowering cholesterol. ACS Appl. Bio Mater., 5, 2377-2388 (2022).
  11. T. Higashi, K. Motoyama, J. Li, Cyclodextrin-based catenanes and polycatenanes. J. Incl. Phenom. Macrocycl. Chem., 102, 569-575 (2022).
  12. T. Taharabaru, T. Kihara, R. Onodera, T. Kogo, K. Higashi, K. Moribe, T. Nakamura, K. Motoyama, T Higashi, Polyrotaxane-based multi-step transformable materials for the delivery of Cas9 ribonucleoprotein. Appl. Mater. Today, 27, 101488 (2022).
  13. Y. Sadahiro, Y. Hitora, I. Kimura, N. Hitora-Imamura, R. Onodera, K. Motoyama, S. Tsukamoto, Colletofragarone A2 Inhibits Cancer Cell Growth In Vivo Leads to the Degradation and Aggregation of Mutant p53. Chem. Res. Toxicol., 9, 1598-1603 (2022).




  1. FY2021 JSPS, Grant-in-Aid for Challenging Research (Exploratory)
  2. FY2022 Grant-in-Aid for Scientific Research (B)
  3. FY2018 JST, CREST
  4. FY2018 AMED

 Ruda LEE

  1. FY2023 Kumamoto Researcher Awards
  2. FY2022 JSPS, Grant-in-Aid for Scientific Research (C)
  3. FY2021 AMED, Infectious Diseases and Immunology Research: U.S.-Japan Cooperative Medical Sciences Program Collaborative Awards
  4. Brain Pool Korea 2022

Ick Chan KWON

  • US patent, Ick Chan Kwon, Ju Hee Ryu, Young-ji Ko, Hye-Sun Kim, Nam-Hyuk Cho, Eun-Jeong Yang, Jae Won Lee. Probe for measuring activity of Caspase-1 and composition for diagnosis of inflammatory diseases containing same. 2023
  • US patent, Ick Chan Kwon, Sun Hwa Kim, YANG Yoosoo, Hyosuk Kim. Method for inducing trans-differentiation of cardiomyocytes based on exosome. 2024
  • US patent, HoWon J Kim, In-San Kim, Jay S Kim, Sun Hwa Kim, Ick Chan Kwon, Jong Won Lee, Yoo Soo Yang, Hong Yeol Yoon. Therapeutic Compounds for Red Blood Cell-Mediated Delivery of an Active Pharmaceutical Ingredient to a Target Cell. 2024


  1. FY2021 JSPS Grant-in-Aid for Scientific Research (C)


  1. FY2022 Grant-in-Aid for Scientific Research (B)
  2. A-step Ikuseigata
  3. The Leading Initiative for Excellent Young Researchers




  1. Takuro Niidome, Anna Kawano, Sayaka Sawada, Tatsuya Baba, Makoto Sasaki, Wei Xu, Graphene Quantum Dots as a Biomaterial: Synthesis and Use of Anti-bacterial and Anti-viral Agents, 44th Annual Meeting of Japanese Society, 2022/11/21, Tokyo, Japan
  2. Takuro Niidome, Ryoko Nawata, Emi Takeda, Ryosuke Suzuki, Wei Xu, Preparation of Silver Nanoplates Encapsulated in PLGA Nanoparticles and Control of their Antibacterial Activity by Laser Light, 38th Annual Meeting of the Japanese Society for Drug Delivery System, Online

Ruda LEE

  1. Ruda Lee, Emerging Role of Nanotechnology for Water Sustainability. Korea International Water Week (KIWW) 2022. 2022/11/24, Daegu, Korea.

      (Dr. Ruda LEE in the center)                               (Group Photo at the venue)

  2. Ruda Lee, Nanoplatform for constructing new approaches to cancer treatment. Kangwon National University, 2022/03/30, Web.



  1. Masamichi Inoue, Takashi Saito, Takaomi C. Saido, Risako Onodera, Taishi Higashi, Keiichi Motoyama, Hirofumi Jono, Design and Evaluation of shRNA Polyplex with Cyclodextrin-modified Dendrimer for Treatment of Systemic and Localized Amyloidosis, The 18th International Symposium on Amyloidosis (online), Heidelberg, Germany, September 4-8 (2022).
  2. Masamichi Inoue, Takashi Saito, Takaomi C. Saido, Risako Onodera, Taishi Higashi, Keiichi Motoyama, Hirofumi Jono Feasibility Study of Cationic Dendrimer-based Polyplex as a Multi-functional Drug for Alzheimer's Disease, The 3rd International Conference on Advanced Materials and Nanotechnology, Singapore, August 18-19 (2022).
  3. Yoshitaka Ohno, Maiko Toshino, Yukio Fujiwara, Yoshihiro Komohara, Risako Onodera, Taishi Higashi, Keiichi Motoyama, Dual-targeting for Colon Cancer Cells and Tumor-Associated Macrophages by Mannose- modified Methyl-β-Cyclodextrins as Antitumor Therapeutic Agents, The 3rd International Conference on Advanced Materials and Nanotechnology, Singapore, August 18-19 (2022).

              (Awarded at the conference)                                    (Meal time at Singapore)


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