Research Clusters

Novel Cancer Medical Technology Using Liquid Biopsy

Research Keyword: Liquid biopsy, Cancer, Detection, Diagnosis, Monitoring

The purpose of this research is to develop palm-sized medical devices for cancer detection, postoperative management, therapy, and drug discovery based on the signals emitted by cells and cells themselves (such as proteins and genes expressed and produced), their responses to stimuli, and the characteristics and properties of cells, such as cell morphology and new technologies to realize such devices.

Ultimately, we will integrate the various elements described above according to the purpose, and try to realize a comprehensive medical system that can consistently perform everything from early detection of cancer to identification of the primary tumor, treatment, and drug administration.


Novel Cancer Medical Technology Using Liquid Biopsy

Cluster members

  • Japan
    Yuta NAKASHIMA Website
    Associate Professor, Research Field of Bioengineering, Division of Biomedical Engineering, Faculty of Advanced Science and Technology, Kumamoto University
  • Singapore
    Chengkuo LEE
    Professor, National University of Singapore
  • Japan
    Wataru IWASAKI
    Chief research officer, National Institute of Advanced Industrial Science and Technology
  • Japan
    Yoichi SAITO Website
    Assistant Professor, Faculty of Advanced Science and Technology, Kumamoto University
  • Japan
    Mami AKAIKE
    Doctoral student, Graduate School of Science and Technology, Kumamoto University



Haruhiko Takemoto, Keito Sonoda, Kanae Ike, Yoichi Saito, Yoshitaka Nakanishi, Yuta Nakashima*, “Development of Cell Micropatterning Technique Using Laser Processing of Alginate Gel,” Journal of Robotics and Mechatronics, 35(5), 1185-1192, 2023.

Yuta Kishimoto, Sachiko Ide, Toyohiro Naito, Yuta Nakashima, Yoshitaka Nakanishi, Noritada Kaji, “Development of a Microfluidic Ion Current Measurement System for Single-Microplastic Detection,” Journal of Robotics and Mechatronics, 35(5), 1193-1202, 2023.

Yoshitaka Nakanishi, Yukio Fujiwara, Yuta Nakashima, Yoshihiro Komohara, Kazunori Hino, Hiromasa Miura, Hidehiko Higaki, “Microchamber device for studying phagocytosis of ultra-high molecular weight polyethylene particles by human monocyte-derived macrophages,” Wear, 523, 204749, 2023.

Yoichi Saito, Yukio Fujiwara, Yuji Miyamoto, Koji Ohnishi, Yuta Nakashima, Yasuhiko Tabata, Hideo Baba, Yoshihiro Komohara, “CD169+ sinus macrophages in regional lymph nodes do not predict mismatch-repair status of patients with colorectal cancer,” Cancer Medicine, 12(9), 10199-10211, 2023.

Yoshitaka Nakanishi, Yukio Fujiwara, Yuta Nakashima, “Generation of Nano/Microplastics for Immunological Assessments,” Biotribology, 33-34, 100235, 2023.

Seitaro Kumamoto, Souichiro Fukuyama, Seiya Nagano, Keiichiro Yasuda, Yusuke Kitamura, Masaaki Iwatsuki, Hideo Baba, Toshihiro Ihara, Yoshitaka Nakanishi, Yuta Nakashima*, “Fabrication of Three-Dimensionally Deformable Metal Structures Using Precision Electroforming,” Micromachines, 13(7), 1046, 2022.

Yoichi Saito, Yukio Fujiwara, Yusuke Shinchi, Remi Mito, Yuji Miura, Tomoya Yamaguchi, Koei Ikeda, Shinji Urakami, Yuta Nakashima, Takuro Sakagami, Makoto Suzuki, Yasuhiko Tabata, Yoshihiro Komohara, “Classification of PD-L1 expression in various cancers and macrophages based on immunohistocytological analysis,” Cancer Science, 113(9), 3255-3266, 2022.

Wataru Iwasaki, Hiroki Toda, Nobutomo Morita, Taisei Motomura, Yuki Fujio, Kenshin Takemura, Yoshitaka Nakanishi, Yuta Nakashima, “A thermoresponsive valve to control fluid flow in microfluidic paper-based devices,” Microfluidics and Nanofluidics, 26, 47, 2022.

Tsugumasa Toma, Hiroshi Tateishi, Kensaku Kawakami, Taha F. S. Ali, Masahiro Kamo, Kazuaki Monde, Yuta Nakashima, Mikako Fujita, and Masami Otsuka, “Novel Inhibitor for Downstream Targeting of Transforming Growth Factor-β Signaling to Suppress Epithelial to Mesenchymal Transition and Cell Migration,” International Journal of Molecular Sciences, 23(9), 5047, 2022.

Hiroki Toda, Wataru Iwasaki, Nobutomo Morita, Taisei Motomura, Kenshin Takemura, Masaya Nagano, Yoshitaka Nakanishi and Yuta Nakashima*, “Reversible Thermo-Responsive Valve for Microfluidic Paper-Based Analytical Devices,” Micromachines, 13(5), 690, 2022.


KAKENHI (Grant-in-Aid for Challenging Research (Exploratory)), ¥ 4,900,000-, Apr. 2023 – Mar. 2025 (Principal Investigator)

KAKENHI (Grant-in-Aid for Scientific Research (B)), ¥ 3,000,000-, Apr. 2020 – Mar. 2023. (Co-Investigator)

Go-Tech (成長型中小企業等研究開発支援事業), ¥ 7,498,400-, Apr. 2023 – Mar. 2024. (Sub-Leader)

Go-Tech (成長型中小企業等研究開発支援事業), ¥ 3,092,949-, Apr. 2023 – Mar. 2024. (Co-Investigator)

JST FOREST, \ 20,000,000-, Apr. 2022 – Mar. 2025. (Principal Investigator)

KAKENHI (Grant-in-Aid for Scientific Research (C)), ¥ 600,000-, Apr. 2022 – Mar. 2025. (Co-Investigator)

 KAKENHI (Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))), \ 2,500,000-, Apr. 2019 – Mar. 2025. (Co-Investigator)


光学測定器用サンプルホルダおよび光学測定器, 特許第7425428号, 2024年1月23日

導光ユニット、吸光度測定装置、およびインキュベータ, 特願2022-007939, 令和4年(2022年)1月21日


Nov. 25-28, 2023:
National University of Singapore, Singapore (→NEWS)

From left, Dr. Lee, Ms. Akaike, and Dr. Nakashima

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