Publications

ACHIEVEMENTS

2020

Aug 18, 2022

Miniaturized crossflow ion transfer device for post-column enrichment in ion chromatography

S. Ohira*, T. Sakaki, R. Miyachi, A. Otsubo, A. Umemoto, Y. Kuwahara, K. Toda

Talanta, 216, 120989 (2020)

https://www.sciencedirect.com/science/article/pii/S0039914020302800
Jul 9, 2021

Optimizing Photoluminescence Quantum Yields in Uranyl Dicarboxylate Complexes: Further Investigations of 2,5‐, 2,6‐ and 3,5‐Pyridinedicarboxylates and 2,3‐Pyrazinedicarboxylate

P. Thuery, Y. Atoini, S. Kusumoto, S. Hayami, Y. Kim, J. Harrowfield,

Eur. J. Inorg. Chem., 46, 4391-4400 (2020).

https://doi.org/10.1002/ejic.202000803
Jul 9, 2021

Solvent-Dependent Bending Ability of Salen-Derived Organic Crystals

S. Kusumoto, A. Saso, H. Ohmagari, M. Hasegawa, Y. Kim, M. Nakamura, L. F. Lindoy, S. Hayami,

ChemPlusChem, 85(8), 1692-1696 (2020).

https://doi.org/10.1002/cplu.202000362
Jul 9, 2021

Ferromagnetically coupled hydroxo-bridged heptanuclear Ni(II) wheel cluster with S= 7 ground spin state

S. Kusumoto, Y. Kim, M. Nakamura, L. F. Lindoy, S. Hayami,

Chem. Lett., 49, 24-27 (2020).

https://doi.org/10.1246/cl.190765
Jul 9, 2021

Microwave-assisted catalytic conversion of glucose to 5-hydroxymethylfurfural using "three dimensional" graphene oxide hybrid catalysts

Y. Hirano, J. N. Beltramini, A. Mori, M, Nakamura, M. R. Karim, Y. Kim, M. Nakamura, S. Hayami,

RSC Adv., 10, 11727-11736 (2020).

https://doi.org/10.1039/D0RA01009J
May 20, 2021

Polymer encapsulation and stabilization of molecular gel-based chiroptical information for strong, tunable circularly polarized luminescence film

H. Oishi, S. Mashima, Y. Kuwahara, M. Takafuji, K. Yoshida, R. Oda, H. Qiu, H. Ihara,

Journal of Materials Chemistry C, Vol.8, pp.8732-8735, 2020
May 20, 2021

Extreme enhancement of secondary chirality through coordination-driven steric changes of terpyridyl ligand in glutamide-based molecular gels

M. Takafuji, T. Kawahara, N. Sultana, N. Ryu, K. Yoshida, Y. Kuwahara, R. Oda, H. Ihara,

RSC Advances, Vol.10, pp. 29627-29632, 2020
May 20, 2021

Chirality induction on non-chiral dye-linked polysilsesquioxane in nanohelical structures

N. Ryu, T. Kawaguchi, H. Yanagita, Y. Okazaki, T. Buffeteau, K. Yoshida, T. Shirosaki, S. Nagaoka, M. Takafuji, H. Ihara, R. Oda,

Chemical Communications, Vol.56, pp.7241-7244, 2020
May 20, 2021

Multi-chiro-informative system created by a porphyrin-functionalized chiral molecular assembly

S. Mashima, N. Ryu, Y. Kuwahara, M. Takafuji, H. Jintoku, R. Oda, H. Ihara,

Chemistry Letters, Vol.49, pp.368-371, 2020
May 18, 2021

Drone Audition Listening from the Sky Estimates Multiple Sound Source Positions by Integrating Sound Source Localization and Data Association

M. Wakabayashi, H.G. Okuno and M. Kumon,

Advanced Robotics, Vol. 34, No. 11, pp. 744-755, doi:10.1080/01691864.2020.1757506, 2020
May 18, 2021

Multi-hop wireless command and telemetry communication system for remote operation of robots with extending operation area beyond line-of-sight using 920 MHz/169 MHz

T. Kagawa, F. Ono, L. Shan, R. Miura, K. Nakadai, K. Hoshiba, M. Kumon, H. G. Okuno, S. Kato and F. Kojima,

Advanced Robotics, Vol. 34, No. 11, pp. 755-766, doi:10.1080/01691864.2020.1760934, 2020
Apr 27, 2021

Serum zinc levels and multiple health outcomes: Implications for zinc-based biomaterials

Xinhua Qu, Hongtao Yang, Zhifeng Yu, Bo Jia, Han Qiao, Yufeng Zheng, Kerong Dai,

Bioactive Materials 5 (2020) 410-422
Apr 26, 2021

Classification of heart sound signals using a novel deep WaveNet model

O. S. Lih, V. Jahmunah, C. P. Ooi, R. S. Tan, E. J Ciaccio, T. Yamakawa, M. Tanabe, M. Kobayashi, U. R. Acharya*,

Computer Methods and Programs in Biomeducune, 196, 105604, 2020. (*corresponding)
Apr 22, 2021

Surface engineering of carbon supported CoMoS– an effective nanocatalyst for selective deoxygenation of lignin derived phenolics to arenes

Swathi Mukundan, Jorge Beltramini, Krishnapillai Girish Kumar, Devika Sudha Ravindran,

Applied Catalysis A, 606, 117811, 2020
Apr 22, 2021

The catalytic activity of KMoCo carbon spheres for higher alcohols synthesis from syngas

Waqas Aslam, Jorge Beltramini, Luqman Atanda,Nundo Batalha, Tobias Schull and Muxina Konarova,

Applied Catalysis, 605, 117803, 2020
Apr 22, 2021

Compressive behaviour of chiral auxetic cellular structures at different strain rates

Novak, N., Vesenjak, M., Tanaka, S., Hokamoto, K., Ren, Z.,

International Journal of Impact Engineering, 141, art. no. 103566.

https://doi.org/10.1016/j.ijimpeng.2020.103566
Apr 22, 2021

An experimental and computational study of the high-velocity impact of low-density aluminum foam

Borovinaek, M., Vesenjak, M., Hokamoto, K., Ren, Z.;

Materials 2020, 13 (8), art. no.1949.

https://doi.org/10.3390/ma13081949
Apr 21, 2021

Temperature-dependent structure of methanol-water mixtures on cooling: X-ray and neutron diffraction and molecular dynamics simulations

Pethes I., Pusztai L., Ohara K., Kohara S., Darpentigny J., Temleitner L.,

J. Mol. Liq., 314, Paper: 113664, 10 p. 2020

https://doi.org/10.1016/j.molliq.2020.113664
Apr 21, 2021

Chloride ions as integral parts of hydrogen bonded networks in aqueous salt solutions: the appearance of solvent separated anion pairs

Pethes I., Bako I., Pusztai L.,

Physical Chemistry Chemical Physics (PCCP), 22, pp. 11038-11044. 2020.
Apr 7, 2021

A dynamically deformable microfilter for selective separation of specific substances in microfluidics

Seitaro Kumamoto, Kenshiro Nakatake, Souichiro Fukuyama, Keiichiro Yasuda, Yusuke Kitamura, Masaaki Iwatsuki, Hideo Baba, Toshihiro Ihara, Yoshitaka Nakanishi, and Yuta Nakashima*,

Biomicrofluidics, 14, 064113, 2020.

https://doi.org/10.1063/5.0025927

*Selected as an Editor’s Pick paper
Apr 7, 2021

Microfluidic Device used for the Secretion of Inflammatory Cytokines from Human Monocyte-Derived Macrophages Stimulated by Ultra-High Molecular Weight Polyethylene Particles

Yoshitaka Nakanishi, Yuta Nakashima, Yukio Fujiwara, Yoshihiro Komohara, Kazunori Hino, Hiromasa Miura, Hidehiko Higaki,

Biotribology, 23, 100137,2020.

https://doi.org/10.1016/j.biotri.2020.100137
Mar 22, 2021

Biological Control of Plant-Parasitic Nematodes by Filamentous Fungi Inducers of Resistance: Trichoderma, Mycorrhizal and Endophytic Fungi

Jorge Poveda, Patricia Abril-Urias and Carolina Escobar,

Frontiers in Microbiology, 11:992, 2020,

https://doi.org/10.3389/fmicb.2020.00992
Feb 25, 2021

Shock loading of closed cell aluminum foams in the presence of an air cavity

Thorat M., Sahu S., Menezes V., Gokhale A., Hosano H.,

Applied Sciences, 10, 12, 4128, 2020.

https://doi.org/10.3390/APP10124128
Feb 16, 2021

Fabrication and mechanical properties of rolled aluminium unidirectional cellular structure

Vesenjak M., Nishi M., Nishi T., Marumo Y., Krstulovi-Opara L., Ren Z., Hokamoto K.,

Metals, 10, 6, 770, 1-12, 2020.

https://doi.org/10.3390/met10060770
Feb 16, 2021

Fabrication of composite unidirectional cellular metals by using explosive compaction

Nishi M., Tanaka S., Vesenjak M., Ren Z., Hokamoto K.,

Metals, 10, 2, 193, https://doi.org/10.3390/met10020193
Feb 16, 2021

Experimental and computational analysis of the uni-directional porous (UniPore) copper mechanical response at high-velocity impact

Nishi M., Tanaka S., Vesenjak M., Ren Z., Hokamoto K.,

International Journal of Impact Engineering, 136, 103409, 2020.

https://doi.org/10.1016/j.ijimpeng.2019.103409
Jan 22, 2021

Establishment of the embryonic shoot meristem involves activation of two classes of genes with opposing functions for meristem activities

Aida M, Tsubakimoto Y, Shimizu S, Ogisu H, Kamiya M, Iwamoto R, Takeda, S, Karim MR, Mizutani M, Lenhard M, Tasaka M,

Int J Mol Sci 21, 5864.

https://doi.org/10.3390/ijms21165864
Dec 24, 2020

Coefficient of variation as an image-intensity metric for cytoskeleton bundling

Takumi Higaki, Kae Akita, Kaoru Katoh,

Sci Rep 10: 22187.

https://www.nature.com/articles/s41598-020-79136-x
Development of ErbB2-Targeting Liposomes for Enhancing Drug Delivery to ErbB2-Positive Breast Cancer

Sho Ueno, Min Woo Kim, Gibok Lee, Yong Il Park, Takuro Niidome, Ruda Lee*,

Pharmaceutics 2020, 12, 585.

https://www.mdpi.com/1999-4923/12/6/585

(*corresponding)
Arabidopsis calcium-dependent protein kinase 3 regulates actin cytoskeleton organization and immunity

Yi-Ju Lu, Pai Li, Masaki Shimono, Alex Corrion, Takumi Higaki, Sheng Yang He, Brad Day,

Nature Communications, 11, 6234, 2020.

https://www.nature.com/articles/s41467-020-20007-4
Mitochondrial dynamics and segregation during the asymmetric division of Arabidopsis zygotes

Yusuke Kimata, Takumi Higaki, Daisuke Kurihara, Naoe Ando, Hikari Matsumoto, Tetsuya Higashiyama, Minako Ueda,

Quant Plant Biol 1: e3.

https://doi.org/10.1017/qpb.2020.4
Breakdown pressure and propagation surface of a hydraulically pressurized circular notch within a rock material

Adam K Schwartzkopff, Noune S. Melkoumian, Chaoshui Xu,

Rock Mechanics and Rock Engineering,

https://doi.org/10.1007/s00603-020-02264-3
Four-dimensional imaging with virtual reality to quantitatively explore jigsaw puzzle-like morphogenesis of Arabidopsis cotyledon pavement cells

Takumi Higaki, Hidenobu Mizuno,

Plant Biotech, 37: 429-435. 2020.

http://doi.org/10.5511/plantbiotechnology.20.0605a
Self-sustaining smouldering combustion of waste: A review on applications, key parameters and potential resource recovery

Hons K. Wyn, Muxina Konarova, Jorge Beltramini, Greg Perkins, Luis Yerman,

Fuel Processing Technology, 205, 106425, 2020.

https://doi.org/10.1016/j.fuproc.2020.106425
Heterogeneous Catalytic Conversion of Sugars Into 2,5-Furandicarboxylic Acid

Athukoralalage Don K. Deshan, Luqman Atanda, Lalehvash Moghaddam, Darryn W. Rackemann, Jorge Beltramini, William O. S. Doherty,

Frontiers in Chemistry, 8:659, 2020.

https://doi.org/10.3389/fchem.2020.00659
Thermocatalytic Hydrodeoxygenation and Depolymerization of Waste Lignin to Oxygenates and Biofuels in a Continuous Flow Reactor at Atmospheric Pressure

Swathi Mukundan, Daria Boffito, Abhijit Shrotri, Luqman Atanda, Jorge Beltramini, Gregory Patience,

ACS Sustainable Chemistry & Engineering, 2020.

https://doi.org/10.1021/acssuschemeng.0c02102
Optimization of chipping parameters to mitigate the damage in a concrete substrate using a discontinuum modelling approach

Taro Sono, Izumi Tanikura, Atsushi Sainoki*, Adam Karl Schwartzkopff, Yuzo Obara,

Construction and Building Materials, Vol. 258, 119658, 2020. (*corresponding)

https://doi.org/10.1016/j.conbuildmat.2020.119658
Stable isotopes show that earthquakes enhance permeability and release water from mountains

Hosono, T., Yamada, C., Manga, M., Wang, C. -Y., Tanimizu, M.,

Nature Communications, 11, 2776, 2020.

https://www.nature.com/articles/s41467-020-16604-y
Expression of a fungal exo-β-1,3-galactanase in Arabidopsis reveals a role of type II arabinogalactans in the regulation of cell shape

Yoshihisa Yoshimi, Katsuya Hara, Mami Yoshimura, Nobukazu Tanaka, Takumi Higaki, Yoichi Tsumuraya, Toshihisa Kotake,

Journal of Experimental Botany, 71, 5414-5424, 2020.

https://doi.org/10.1093/jxb/eraa236
Semi-continuous Monitoring of Cr(VI) and Cr(III) during a Soil Extraction Process by Means of an Ion Transfer Device and Graphite Furnace Atomic Absorption Spectroscopy

Willy Cahya NUGRAHA, Haruka NGAI, Shin-Ichi OHIRA, Kei Toda,

Analytical Sciences, 36, 617-620, 2020.

https://doi.org/10.2116/analsci.19SBN02
The atypical E2F transcription factor DEL1 modulates growth–defense tradeoffs of host plants during root-knot nematode infection

Satoru Nakagami, Kentaro Saeki, Kei Toda, Takashi Ishida, Shinichiro Sawa,

Scientific Reports, 10(1), 8836, 2020.

https://doi.org/10.1038/s41598-020-65733-3
Near Infrared Light Triggered Photo/Immuno-therapy Towards Cancers

Xiaoxue Xu, Hongxu Lu, Ruda Lee,

Frontiers in Bioengineering and biotechnology, 8, 488. May 2020.

https://doi.org/10.3389/fbioe.2020.00488
Elevated CO2 promotes satellite stomata production in young cotyledons of Arabidopsis thaliana

Takumi Higaki, Kae Akita, Seiichiro Hasezawa,

Genes Cells, 25: 475-482. 2020.

https://doi.org/10.1111/gtc.12773
Root-knot nematodes modulate cell walls during root-knot formation in Arabidopsis roots

Takashi Ishida, Reira Suzuki, Satoru Nakagami, Takeshi Kuroha, Shingo Sakamoto, Miyuki T. Nakata, Ryusuke Yokoyama, Seisuke Kimura, Nobutaka Mitsuda, Kazuhiko Nishitani, Shinichiro Sawa,

Journal of Plant Research, 133(3), 419-428, 2020.

https://doi.org/10.1007/s10265-020-01186-z
Root-knot nematodes induce gall formation by recruiting developmental pathways of post-embryonic organogenesis and regeneration to promote transient pluripotency

Rocio Olmo, Javier Cabrera, Fernando E. Diaz-Manzano, Virginia Ruiz-Ferrer, Marta Barcala, Takashi Ishida, Alejandra Garcia, Maria Fe Andres, Simon Ruiz-Lara, Isabel Verdugo, Monica Pernas, Hidehiro Fukaki, Juan Carlos del Pozo, Miguel Angel Moreno-Risueno, Tina Kyndt, Godelieve Gheysen, Carmen Fenoll, Shinichiro Sawa and Carolina Escobar,

New Phytologist, 227(1), 200-215, 2020.

https://doi.org/10.1111/nph.16521
AT-hook transcription factors restrict petiole growth by antagonizing PIFs

David S Favero, Ayako Kawamura, Michitaro Shibata, Arika Takebayashi, Jae-Hoon Jung, Takamasa Suzuki, Katja E Jaeger, Takashi Ishida, Akira Iwase, Philip A Wigge, Michael M Neff, Keiko Sugimoto,

Current Biology, 30(8), R354-356, 2020.

https://doi.org/10.1016/j.cub.2020.02.017
Coseismic hydro-environmental changes: insights from recent earthquakes

Hosono, T., Saltalippi, C., Jean, J.-S.,

Journal of Hydrology, 585, 124799, 2020.
Multiple Sound Source Position Estimation by Drone Audition Based on Data Association Between Sound Source Localization and Identification

M. Wakabayashi, H. G. Okuno and M. Kumon,

IEEE Robotics and Automation Letters, 5(2), 782-789, 2020.
Near-infrared light-triggered photodynamic therapy and apoptosis using upconversion nanoparticles with dual photosensitizers

Song Yeul Lee, Ruda Lee†, Eunha Kim, Sanghee Lee, Yong Il Park,

Frontiers in Bioengineering and Biotechnology, 8, 275. Apr. 2020.

https://doi.org/10.3389/fbioe.2020.00275

(†co-first)
Hourly-scale coastal sea level modeling in a changing climate using long short-term memory neural network

Kei Ishida, Gozo Tsujimoto, Ali Ercan, Tongbi Tu, Masato Kiyama, Motoki Amagasaki,

Science of The Total Environment, 720, 2020.

https://www.sciencedirect.com/science/article/pii/S0048969720311244?dgcid=author
Hyaluronic Acid-Decorated Glycol Chitosan Nanoparticles for pH-Sensitive Controlled Release of Doxorubicin and Celecoxib in Nonsmall Cell Lung Cancer

Ruda Lee, Yu Jin Choi, Myeong Seon Jeong, Yong Il Park, Keiichi Motoyama, Min Woo Kim, Seung-Hae Kwon, Jung Hoon Choi,

Bioconjugate Chem., 31(3), 923-932, 2020.

https://doi.org/10.1021/acs.bioconjchem.0c00048
Mesenchymal-Epithelial Transition Regulates Initiation of Pluripotency Exit before Gastrulation

Sofiane Hamidi, Yukiko Nakaya, Hiroki Nagai, Cantas Alev, Takeya Kasukawa, Sapna Chhabra, Ruda Lee, Hitoshi Niwa, Aryeh Warmflash, Tatsuo Shibata, and Guojun Sheng,

Development, 147(3), dev184960, 2020.
Platelet-like gold nanostars for cancer therapy: the ability to treat cancer and evade immune reactions

Min Woo Kim, Gibok Lee, Takuro Niidome, Yoshihiro Komohara, Ruda Lee*, Yong Il Park,

Frontiers in Bioengineering and Biotechnology, 8, p133, 2020. (*co-corresponding)
Non-invasive early detection of calpain 2-enriched non-small cell lung cancer using a human serum albumin-bounded calpain 2 nanosensor

Kwon SH, Wi T, Park YI, Kim MW, Lee G, Higaki T, Choi JH, Lee R,

Bioconjug Chem., 31(3), 803-812, 2020.

https://doi.org/10.1021/acs.bioconjchem.9b00870
Actin filament disruption alters phragmoplast microtubule dynamics during the initial phase of plant cytokinesis

Keisho Maeda, Michiko Sasabe, Shigeru Hanamata, Yasunori Machida, Seiichiro Hasezawa, Takumi Higaki,

Plant Cell Physiol., 61(3), 445-456, 2020.

https://academic.oup.com/pcp/advance-article/doi/10.1093/pcp/pcaa003/5716757
Bio-lubricants synthesis from the epoxidized oil promoted by clays: Kinetic modelling

Tesser, R., Russo, V., Turco, R., Vitiello, R., & Di Serio, M.,

Chemical Engineering Science, 214, 2020.

https://doi.org/10.1016/j.ces.2019.115445
Comparison of different possible technologies for epoxidation of cynara cardunculus seed oil

Turco, R., Tesser, R., Russo, V., Vitiello, R., Fagnano, M., & Di Serio, M.,

European Journal of Lipid Science and Technology, 122(1), 2020.

https://doi.org/10.1002/ejlt.201900100
Automated detection of heart valve diseases using chirplet transform and multiclass composite classifier with PCG signals

S. K. Ghosh, R.N. Ponnalagu, R.K. Tripathy, U. R. Acharya,

Computers in Biology and Medicine, 118, 103632, 2020.

https://doi.org/10.1016/j.compbiomed.2020.103632
A computational intelligence tool for the detection of hypertension using empirical mode decomposition

D. Soh, E. Y. K. Ng, V. Jahmunah, S. L. Oh, R. S. Tan, U. R. Acharya,

Computers in Biology and Medicine, 118, 103630, 2020.

https://doi.org/10.1016/j.compbiomed.2020.103630
1D-CADCapsNet: One dimensional deep capsule networks for coronary artery disease detection using ECG signals

E. Butun, O. Yildirim, M. Talo, R. S. Tan, U. R. Acharya,

Physica Medica, 70, 39-48, 2020.
Comprehensive electrocardiographic diagnosis based on deep learning

O. S. Lih, V. Jahmunah, R. S. Tan , E. J Ciaccio, T. Yamakawa, M. Tanabe, M. Kobayashi, O. Faust, U. R. Acharya*,

Artificial Intelligence In Medicine, 103, 101789, 2020. (*corresponding)
Controllable biodegradation and enhanced osseointegration of ZrO2 nanofilm coated Zn-Li alloy: in vitro and in vivo studies

Wei Yuan, Dandan Xia, Y.F. Zheng, Xiangmei Liu, Shuilin Wu, Bo Li, Yong Han, Zhaojun Jia, Donghui Zhu, Liqun Ruan, Kazuki Takashima, Yunsong Liu, Yongsheng Zhou,

Acta Biomaterialia 105 (2020) 290-303

https://doi.org/10.1016/j.actbio.2020.01.022
Impact of the intermediate stress component in a plastic potential function on rock mass stability around a sequentially excavated large underground cavity,

Atsushi Sainoki, Duncan Maina, Adam Karl Schwartzkopff, Yuzo Obara, and Murat Karakus,

International Journal of Rock Mechanics and Mining Science, 127, 104223, 2020.
Dynamic Modelling of Induced Seismicity by Using Seismic Efficiency Constraints and a New Scaling Law for Slip-Weakening Distance,

Atsushi Sainoki, Chiaki Hirohama, Adam Schwartzkopff,

Pure and Applied Geophysics, 177, 637-659, 2020.

https://doi.org/10.1007/s00024-019-02342-w
Crack front geometry and stress intensity factor of semi-circular bend specimens with straight through and chevron notches,

Y. Obara, K. Nakamura, S. Yoshioka, A. Sainoki, A. Kasai,

Rock Mechanics and Rock Engineering, 53, 723-738, 2020.

https://doi.org/10.1007/s00603-019-01930-5
Alloying design of biodegradable zinc as promising bone implants for load-bearing applications

Hongtao Yang, Bo Jia, Zechuan Zhang, Xinhua Qu, Guannan Li, Wenjiao Lin, Donghui Zhu, Kerong Dai, Yufeng Zheng,

Nature Communications, 11, 401, 2020.

https://doi.org/10.1038/s41467-019-14153-7
Preparation of biodegradable PLGA-nanoparticles used for pH-sensitive intracellular delivery of an anti-inflammatory bacterial toxin to macrophages,

Ayaka Harada, Hiroyasu Tsutsuki, Tianli Zhang, Ruda Lee, Kinnosuke Yahiro, Tomohiro Sawa, Takuro Niidome,

Chem. Pharm. Bull., 68(4), 363-368, 2020.
The progression of xylem vessel cell differentiation is dependent on the activity level of VND7 in Arabidopsis thaliana,

Risaku Hirai, Takumi Higaki, Yuto Takenaka, Yuki Sakamoto, Junko Hasegawa, Sachihiro Matsunaga, Taku Demura, Misato Ohtani,

Plants, 9(1), 39, 2020.

https://www.mdpi.com/2223-7747/9/1/39
Structural, rheological and dynamic aspects of hydrogen-bonding molecular liquids: Aqueous solutions of hydrotropic tert-butyl alcohol

Jure Cerar, Andrej Jamnik, Ildiko Pethes, Laszlo Temleitner, Laszlo Pusztai, Matija Tomsic,

Journal of Colloid and Interface Science, 560, 730-742, 2020.

https://doi.org/10.1016/j.jcis.2019.10.094