Dr. Kazuki TAKASHIMA
International Research Organization for Advanced Science and Technology
Dr. Kei TODA
Faculty of Advanced Science and Technology
Dr. Jorge Norberto BELTRAMINI
Adjunct Professor-Catalysis for Clean Energy Group Leader
Center for Tropical Crops & Bio-Commodities-Faculty of Science &Engineering
Queensland University of Technology (QUT), AustraliaResearch Interests: Catalysis, material science, energy
Dr. Konstantinos KONTIS
Professor, Head of the Aerospace Sciences Division
Sir Henry Mechan Chair of Engineering
School of Engineering,
University of Glasgow, UKResearch Interests: Aerospace engineering
Dr. László PUSZTAI
Wigner Research Centre for Physics,
Hungarian Academy of Sciences, HungaryResearch Interests: Structure of liquid and amorphous materials
Dr. Yufeng ZHENG
Department of Materials Science and Engineering,
College of Engineering, Peking University, ChinaResearch Interests: Metallic biomaterials
Dr. Mitsuhiro AIDAResearch Interests: Plant growth and development, morphogenesis, transcriptional regulation
Plant growth and development is highly dependent on a small stem cell containing tissue called the shoot meristem, which is located at the tips of the plant body. The aim of our lab is to understand molecular and cellular mechanisms on how shoot meristems are formed, how organ formation from the meristems are controlled and how meristem activity is regulated upon various developmental and environmental cues, by using genetics, imaging techniques, biochemistry and genomics.
1.Mechanisms of shoot meristem formation
We focus on a set of transcription factors named CUP-SHAPED COTYLEDON (CUC) 1, 2 and 3, whose activities are essential for shoot meristem formation in diverse developmental contexts. We are currently identifying and analyzing downstream genes of the CUC proteins and try to understand how the process of shoot meristem formation is regulated and coordinated.
2.Flower development and meristem activity
The flower is a complex organ system specialized for reproduction and is formed from a modified meristem called the floral meristem. Through identifying factors responsible for floral meristem development, we try to uncover molecular and cellular mechanisms that govern flower formation.
Technician Kazuko ONGA
Tenure-track Associate Professors
Dr. Takumi HIGAKIResearch Interests: Quantitative bioimaging, cell morphogenesis, cytoskeleton and organelles
Actin filaments of plants
Actin, a protein that is ubiquitous in eukaryotes, forms actin filaments by its polymerization under physiological conditions. Actin filaments are deeply involved in cell morphological changes through formation of higher-order structures such as networks and bundles. In the case of plant cells in particular, actin filaments regulate various organelle dynamics. We aim for visible understanding of actin filament roles in cell division, cell expansion, and cell death, in which plant cell undergoes drastic changes.
Stomatal development and movement
The stomata on the plant leaf and stem surfaces is essential for plant survival because they are responsible for gaseous exchange and transpiration. The stomatal density and aperture is appropriately regulated in response to environmental cues. Using multiple approaches including biochemistry, molecular biology, live cell imaging, image analysis, and mathematical modeling, we aim for visible understanding of the multi-scale spatiotemporal control mechanism of plant stomata.
Image analysis tool development
When addressing problems in the cell biological studies described above, quantitative evaluations of cell structure and movement involving microscopic image analyses are essential. However, existing image analysis softwares are frequently insufficient. This is because the acquired image types and objectives are highly diversified in cell biology studies. For this reason, we are developing image analysis tools that would promote research progress from the standpoint of experimental cell biologists.
Technician Remi KAWAKAMI
Dr. Ruda LEEResearch Interests: Molecular engineering, molecular imaging, nanomedicine, and drug delivery
Prof. Ruda Lee, PH.D.
International Research Organization for Advanced Science and Technology (IROAST), Kumamoto University, Japan
Ph.D., Korea University, School of Medicine (2013)
2017-present Associate Professor (Kumamoto University, Japan) 2014-2016 Postdoctral fellow (IIT, Italy) 2013-2014 Postdoctral fellow (KIST, Korea) 2009-2013 MS & Ph.D course trainee (KIST, Korea) 2008-2009 Research Assistant (KIST, Korea)
Selected peer-reviewed publications
- Lee A et al. Early diagnosis of arthritis in mice with collagen-induced arthritis, using a fluorogenic MMP 3-specific polymeric probe. Arthritis Rheum 2011
- Lee A et al. Measurement of MMP Activity in Synovial Fluid in Cases of Osteoarthritis and Acute Inflammatory Conditions of the Knee Joints Using a Fluorogenic Peptide Probe-Immobilized Diagnostic Kit. Theranostics 2012
- Lee A et al. A novel near-infrared fluorescence chemosensor for copper ion detection using click ligation and energy transfer. Chem Commun 2013
- Lee A et al. TNF-α Gene Silencing Using Polymerized siRNA/Thiolated Glycol Chitosan Nanoparticles for Rheumatoid Arthritis. Mol Ther 2014
- Lee A et al. Spherical Polymeric Nanoconstructs for Combined Chemotherapeutic and anti-Inflammatory Therapies. Nanomedicine : NBM 2016
- Lee A et al. Dexamethasone-loaded nanoconstructs for treating and monitoring inflammation in murine colitis models”, Theranostics 2017
Research in the Lee lab develops novel molecular imaging sensors and multifunction drug delivery carriers for ‘Theragnosis’ (Therapy + Diagnosis).
1. Enzyme specific activated imaging sensor based real-time in vivo imaging
Proteases are among the most studied enzyme families due to their involvement in the regulation of diverse disease processes and their potential value as biomarkers and therapeutic targets. We reported various protease target Near-infrared fluorescence (NIRF) imaging sensors and detecting pathologic processes at the cellular and molecular levels in vivo, such as cancer, arthritis, brain disorder and inflammation.
2. Active targeting drug delivery nanomaterials
Active targeted drug delivery material delivers a therapeutic and/or diagnostic agent to a targeted diseased area. Drug-loaded nanomaterials (NPs) are decorated by the peptide, aptamer, antibody for recognition by specific receptors/antigens on target cells. In this strategy, NPs can avoid non-specific biodistribution, reducing cytotoxicity and treatment dosage. It could provide patients to have chances of effective therapeutic treatment.
3. Stimuli responsive controlled drug release system
Owing to precise stimuli response, stimuli-responsive DDSs can control drug release, so as to improve the curative effects, reduce the damage of normal tissues and organs, and decrease the side effects of traditional anticancer drugs. We designed endogenous stimuli-responsive materials (pH, enzyme and redox responsive) and exogenous stimuli-responsive materials (such as light and ultrasound).
Associate Prof. Ruda Lee Post. doc Students M1 Sho Ueno B4 Naoki Furutachi B4 Sho Tanigawa
Tenure-track Assistant Professor
Dr. Takashi ISHIDAResearch Interests: Plant stem cell and development
I. Analyses of peptide hormone mediated intercellular communications in shoot meristem.
Coordinated cell proliferation and cell differentiation are essential processes in multicellular organisms. To achieve these functions, organisms have developed scrupulously designed cell-to-cell communication systems over the course of evolution. Plants have established unique ligand-receptor-based signaling modules, such as the CLAVATA (CLV) pathway, which comprises the CLV3 peptide hormone and the extracellular leucine-rich repeat (LRR) domain-containing receptors. In the shoot apical meristem (SAM) of Arabidopsis thaliana (Arabidopsis), CLV signal transducers and WUSCHEL (WUS), a homeobox transcription factor, form a negative feedback loop that controls the number of stem cells.
Recently, I have showed that the Arabidopsis G protein beta-subunit1 (AGB1) is involved in the CLV signaling pathway. agb1 mutant exhibits an enlarged SAM and increased number of carpel, similar to that of clv mutants. We are aiming to elucidate further molecular insights of these proteins.
Reference : Ishida et al., EMBO rep, 2014
II. Exploring molecular machineries that regulate stem cell activities in root meristem.
Coordination between cell proliferation and cell differentiation is important also in root meristem. Plants require the cell-to-cell communication system to regulate their activities and to ensure for precise postembryonic development. Shoot and root systems are thought to share common mechanism for carrying out this process; however, its molecular basis is largely unclear. It has been suggested that synthetic CLV3/ EMBRYO SURROUNDING REGION (CLE) peptide treatment shrank the root meristem through the CLV-related receptors in Arabidopsis.
I have identified several molecules that are involved in the CLV-like signaling pathway in root, e.g. BAM1, RPK2 and PUB4. Mutation in these genes decreased sensitivity to the CLE-peptides. Further, we have found that several signaling factors are expressed in limited cells of the root meristem, suggesting that these cells may be responsible for the CLE peptide-stimulated shrinkage of root meristem. We are deciphering what types of cells are involved in the regulatory mechanisms in the root meristem.
Reference : Kinoshita et al., Development, 2015; Shimizu et al., New phytol, 2015
III. Phytoparasitic nematodes hijack vascular stem cells
The developmental plasticity is one of the most striking features of plant morphogenesis, as plants are able to vary their shapes in response to environmental cues. Biotic or abiotic stimuli often promote organogenesis in plants that is not observed under normal growth conditions. Root-knot nematodes (RKNs) are known to parasitize multiple species of rooting plants and to induce characteristic tissue expansion called galls or root-knots (RKs), on the roots of their hosts by perturbing the plant cellular machinery. RKs contain giant cells (GCs) and neighboring cells (NCs), and the GCs are a source of nutrients for the parasitizing nematode. Highly activated cell proliferation was observed in galls. However, the underlying mechanisms that regulate the symptoms that are triggered by the plant-animal interaction have not yet been elucidated.
We have established in vitro infection assay system with Meloidogyne incognita. By utilizing the in vitro system, we are trying to understand how the nematodes modulate developmental regulation mechanisms of plant cells to ensure the atypical cell proliferation and GC formation during the infection processes.
Yamaguchi et al., Front Plant Sci, 2017
Technician Mika YOSHIMURA
Project Assistant Professor
Dr. Akiko NAKAMASU
Higaki LabResearch Interests: Pattern formation, plant morphogenesis, and theoretical and mathematical biology
Dr. Mizuki YAMADA
Aida LabResearch Interests: Plant morphogenesis, plant signaling
Young Faculty Members for International Joint Research
Dr. Takahiro HOSONO
Faculty of Advanced Science and TechnologyResearch Interests: Environment dynamics analysis, Environmental assessment, Hydro-environmental science, Environmental isotope science, Natural disasters
Dr. Kei Ishida
Center for Water Cycle, Marine Environment and Disaster ManagementResearch Interests: Hydrology
Dr. Mizue MUNEKATA
Advanced Thermal and Fluid Energy System Group, Division of Industrial Fundamentals, Faculty of Advanced Science and TechnologyResearch Interests: Fluid engineering
Dr. Yuta NAKASHIMA
Faculty of Advanced Science and TechnologyResearch Interests: Biomedical engineering, Biomedical devices
Dr. Masayuki TANABE
Signal and Information Processing Group, Division of Environmental Science,
Faculty of Advanced Science and TechnologyResearch Interests: Ultrasound Imaging, Signal Processing
Dr. U Rajendra ACHARYA
Senior faculty member
Ngee Ann Polytechnic, SingaporeResearch Interests: Signal and Image processing and Artificial Intelligence
Dr. José E. ANDRADE
California Institute of Technology (Caltech),USAResearch Interests: Developing a fundamental understanding of the multiscaleand multiphysical behaviors of porous materials—everything from soils, rocks, and concrete to bone.
Behavior of granular materials like sand, snow, and even grain stored in silos.
Dr. Josep-Lluís BARONA-VILAR
Institute of History of Medicine and Science López Piñero (IHMC),
University of Valencia, SpainResearch Interests: History of science, history of medicine
Dr. Pouyan BOUKANY
Delft University of Technology,
NetherlandsResearch Interests: Living Soft Matter, complex fluids, biomicrofluidics and biomechanics
Dr. Olivier BOUTIN
Professor Deputy Director M2P2, Director Master Chemical Engineering
M2P2 Laboratory, Aix Marseille University, FranceResearch Interests: Chemical engineering, high pressure and high temperature process for waste treatment and biomass valorisation, Wet air oxidation.
Dr. Paul BOWEN
School of Metallurgy and Materials
University of Birmingham, UKResearch Interests: Characterisation, development, fracture and fatigue of alloys and composite materials (MMCs and CMCs), etc. Please see below.
Dr. Pierre BREUL
University of Clermont Auvergne, FranceResearch Interests: Soils and granular materials mechanics
Dr. Maria Jose COCERO
Chemical Engineering & Environmental Technology
The University of Valladolid, SpainResearch Interests: Development of biorefinery processes and products.
Healthy and high added value products from renewable raw materials.
Intensification of processes through the implementation of new technologies for revaluation of raw materials and waste.
Energy and fuels for the sustainable development.
Dr. Marc DE BOISSIEU
SIMaP, CNRS, Université Grenoble Alpes, FranceResearch Interests: Quasicrystals, structure, phonon and phason,
Coherent x-ray diffraction imaging,
Ge based clathrates
Dr. Patrice DELMAS
Department of Computer Science,
The University of Auckland, New ZealandResearch Interests: Image processing techniques applied to soil science, 2D/3D medical imaging, Theoretical and Applied Computer Vision at large
Dr. Martin DIENWIEBEL
Karlsruhe Institute for Technology (KIT), GermanyResearch Interests: Tribology, surface science, nanotribology
Dr. Martino DI SERIO
University of Naples Federico II, ItalyResearch Interests: Catalysis, Green Chemistry
Dr. Derek ELSWORTH
Department of Energy and Mineral Engineering and of Geosciences
The Pennsylvania State University, USAResearch Interests: Computational mechanics, rock mechanics, and in the mechanical and transport characteristics of fractured rocks
Dr. Carolina ESCOBAR
Department of Environmental Sciences
School of Environmental Sciences and Biochemistry
University of Castilla La Mancha, SpainResearch Interests: Phytopathology (Molecular knowledge of the Plant-nematode interaction and nematodes control)
Dr. Amir A. FARAJIAN
Department of Mechanical and Materials Engineering
Wright State University, USAResearch Interests: Nanoscience and nanotechnology with emphasis on computational modeling, sensors, materials for renewable energy, inelastic response, nano- and molecular-electronics, nanoelectromechanical systems, electronic and thermal quantum transports, bio-inspired nanomaterials.
Dr. Etsuko FUJITA
Brookhaven National Laboratory, USAResearch Interests: Photochemistry of transition-metal complexes, organometallic compounds, and band-gap-narrowed semiconductors; photochemical and electrochemical CO2 reduction and water splitting; small molecule activation
Dr. Tomonari FURUKAWA
Department of Mechanical and Aerospace Engineering
University of Virginia, USAResearch Interests: Robotics, autonomous systems, computational/experimental mechanics
Dr. Hamid GHANDEHARI
Director of Utah Center for Nanomedicine,
Professor of Department of Pharmaceutics and Pharmaceutical Chemistry and Bioengineering,
University of Utah, USAResearch Interests: Engineering biomaterials for delivery of bioactive agents, toxicology of engineered nanoconstructs
Dr. Olivier HAMANT
INRA, RDP, ENS Lyon, FranceResearch Interests: Plant development, mechanical signals
Dr. Christian HARDTKE
Department of Plant Molecular Biology, University of Lausanne, SwitzerlandResearch Interests: Plant development, vascular differentiation, plant hormones, peptide signalling
Dr. Jens HARTMANN
Institute for Geology, Universität Hamburg, GermanyResearch Interests: Aquatic geochemistry, global biogeochemical cycles
Dr. Yuichiro HIMEDA
Prime Senior Researcher
Carbon-based Energy Carrier Research Team, Global Zero Emission Research Center, National Institute of Advanced Industrial Science and Technology, JapanResearch Interests: CO2 utilization, Homogeneous catalyst, Hydrogen carrier
Dr. Dragos HORVATH
CNRS Research Director
Laboratory of Chemoinformatics UMR7140
University of Strasbourg, FranceResearch Interests: Chemoinformatics, Computer-aided Drug Design, Molecular Modeling, Implicit Solvent Models, Nature-Inspired Optimization Heuristics
Dr. Yang KIM
Kosin University, KoreaResearch Interests: Supramolecular chemistry, chemosensor
Dr. Alexei KUZMIN
Head of Laboratory
EXAFS Spectroscopy Laboratory
Institute of Solid State Physics, University of Latvia, Riga, LatviaResearch Interests: X-ray absorption spectroscopy, computer simulations, oxide materials
Dr. Ick Chan KWON
Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, USA
Principal Research Scientist
Biomedical Research Institute, Korea Institute of Science and Technology (KIST), KoreaResearch Interests: Drug delivery system, molecular imaging, theragnosis, nanomedicine
Dr. Youn-Woo LEE
School of Chemical and Biological Engineering,
Seoul National University, KoreaResearch Interests: Supercritical Fluid Technology
Dr. Pavel LEJČEK
Institute of Physics, Academy of Sciences of the Czech Republic, Czech Republic, AND
University of Chemistry and Technology, Prague, Czech RepublicResearch Interests: Metallurgy, materials science
Dr. Viren Ivor MENEZES
Department of Aerospace Engineering,
Indian Institute of Technology Bombay, IndiaResearch Interests: Applications of shock waves and hypersonic aerothermodynamics
Dr. Matthieu MICOULAUT
Sorbonne University, FranceResearch Interests: Glasses, liquids.
Glass transition, structure of disordered materials.
Dr. Dmitri Aleks MOLODOV
Institute of Physical Metallurgy and Metal Physics,
RWTH Aachen University, GermanyResearch Interests: Characterization and control of micro-structure evolution in polycrystalline solids; Dynamic properties of interfaces in metals and alloys; Crystal plasticity
Dr. Rahul Raveendran NAIR
National Graphene Institute and School of Chemical Engineering and Analytical Science
The University of Manchester, UKResearch Interests: Materials physics, 2D materials, nanoscience and nanotechnology, 2D materials based membranes and coating, nanofluidics
Dr. Reiko ODA
CBMN UMR5248, CNRS,
University of Bordeaux, FranceResearch Interests: Colloid/surfactant chemistry, physical chemistry
Dr. Shie-Ming PENG
Distinguished Research Professor
National Taiwan University, TaiwanResearch Interests: Inorganic Chemistry; Crystallography; Nano Science.
Structure and Bonding of Transition Metal Complexes; Metal-Metal Bonds; Molecular Metal Wires; Molecular Electronics.
Dr. Ramesh Shanmughom PILLAI
Department of Molecular Biology,
University of Geneva, SwitzerlandResearch Interests: RNA biology and epigenetics
Dr. Zoran REN
Faculty of Mechanical Engineering,
University of Maribor, SloveniaResearch Interests: Advanced computation solid mechanics, cellular materials, impact and dynamics
Dr. Christian RENTENBERGER
Faculty of Physics
University of Vienna, AustriaResearch Interests: Structure and properties of nanocrystalline and amorphous materials, electron microscopy methods
Dr. Stelios RIGOPOULOS
Reader in Thermofluids
Department of Mechanical Engineering
Imperial College London, UKResearch Interests: Population balance modelling, aerosol science, fluid mechanics, reacting flows, LES/DNS, PDF methods, combustion, crystallisation, chemical kinetics, machine learning.
Dr. Shirley SHEN
Principal Research Scientist
Commonwealth Scientific and Industrial Research Organisation (CSIRO), AustraliaResearch Interests: Nanomaterials, Surfacel interphase designs and embedded functions
Dr. Atsushi URAKAWA
Delft University of Technology (TU Delft), the NetherlandsResearch Interests: Heterogeneous catalysis, in situ / operando spectroscop
Dr. Gioacchino (Cino) VIGGIANI
Solid Mechanics and Civil Engineering
Université Grenoble Alpes, FranceResearch Interests: Geomechanics
Dr. Thomas WAITZ
Associate University Professor
Faculty of Physics, University of Vienna, AustriaResearch Interests: Nanostructured materials, shape memory alloys, phase transformations, transmission electron microscopy
Dr. Andrew WHITTLE
Professor of Civil & Environmental Engineering
Massachusetts Institute of Technology (MIT), USAResearch Interests: Geotechnical, urban infrastructure
Dr. Zhenghe XU
College of Engineering,
Southern University of Science and Technology, Shenzhen, China
Department of Chemical and Materials Engineering, University of Alberta, Edmonton, CanadaResearch Interests: Engineering of nano particles and composites for bio, energy and environmental applications, etc.
Dr. Firuz ZARE
Power and Energy Group,
The University of Queensland, AustraliaResearch Interests: Power electronics and energy conversion
Visiting Associate Professors
Dr. Tomoyasu MANI
Department of Chemistry, University of Connecticut, USAResearch Interests: Electron and energy transfer, spin chemistry
Dr. Daniel P. ZITTERBART
Woods Hole Oceanographic Institution
USAResearch Interests: Marine Animal Remote Sensing
|Senior Administrator||Tomomi MAEDA|
|Staff Member||Takayuki UENO|
|Research Support Associate||Tae SATO|
|Clerical Assistant||Akiko TAJIRI|
|International Coordinator||Junko MOTOORI|