Dr. Kazuki TAKASHIMA
International Research Organization for Advanced Science and TechnologyResearch Interests: Fracture and Fatigue, Mechanical Properties, Materials Evaluation
1. Development of Testing Methods for Micro-Sized Materials
Since thin films are used as structural materials in MEMS (Micro Electro Mechanical System) devices, it is necessary to accurately measure the mechanical properties of thin films in order to improve the reliability and durability of the devices. We are developing testing methods for micron to submicron size components fabricated from thin films. The results obtained will greatly contribute to the development of MEMS devices.
Fig. 1 Examples of micro-sized specimens for tensile, bending, fracture and fatigue tests.
Fig. 2 Micro-materials testing machine developed in our laboratory. We are measuring the deformation, fracture, and fatigue behavior of micro-sized materials using this testing machine.
2. Evaluation of Mechanical Properties of Hierarchical Microstructures in Materials
The mechanical properties of a bulk material depend on the mechanical properties of its microstructure, such as grain size and precipitates, and microstructural control improves the material properties. Therefore, investigating the mechanical properties at such a microscopic level will lead to the development of new materials with superior mechanical properties. In this research, we evaluate the mechanical properties of advanced materials, including high strength steels, Ti alloys and Mg alloys, at the microstructure level to elucidate the deformation and fracture mechanisms and to develop high-strength and high-toughness materials. This laboratory is the only one in the world that conducts such research, and the results are highly anticipated.
Fig. 3 If micro-sized specimens are prepared from micro-constituents in materials, and micromechanical testing is performed for such specimens, the mechanical properties, including grain boundary strength, fracture toughness of precipitate, interfacial strength between matrix and secondary phase, etc., can be measured. The evaluation of mechanical properties of microstructure is essential for the designing high strength material.
Fig.4 Preparation of micro-sized specimens from the constituents of material structure
Fig. 5 Deformation behavior and strain distribution are measured to elucidate deformation and fracture mechanisms.
Dr. Kei TODA
Faculty of Advanced Science and TechnologyResearch Interests: Analytical chemistry, Atmospheric chemistry, Environmental chemistry
Dr. Konstantinos KONTIS
Professor, Head of the Aerospace Sciences Division
Sir Henry Mechan Chair of Engineering
School of Engineering,
University of Glasgow, UKResearch Interests: Aerospace engineering
Dr. László PUSZTAI
Wigner Research Centre for Physics
HungaryResearch Interests: Structure of liquid and amorphous materials
Dr. Yufeng ZHENG
Department of Materials Science and Engineering,
College of Engineering, Peking University, ChinaResearch Interests: Metallic biomaterials
Dr. Mitsuhiro AIDAResearch Interests: Plant growth and development, morphogenesis, transcriptional regulation
Plant growth and development is highly dependent on a small stem cell containing tissue called the shoot meristem, which is located at the tips of the plant body. The aim of our lab is to understand molecular and cellular mechanisms on how shoot meristems are formed, how organ formation from the meristems are controlled and how meristem activity is regulated upon various developmental and environmental cues, by using genetics, imaging techniques, biochemistry and genomics.
1.Mechanisms of shoot meristem formation
We focus on a set of transcription factors named CUP-SHAPED COTYLEDON (CUC) 1, 2 and 3, whose activities are essential for shoot meristem formation in diverse developmental contexts. We are currently identifying and analyzing downstream genes of the CUC proteins and try to understand how the process of shoot meristem formation is regulated and coordinated.
2.Flower development and meristem activity
The flower is a complex organ system specialized for reproduction and is formed from a modified meristem called the floral meristem. Through identifying factors responsible for floral meristem development, we try to uncover molecular and cellular mechanisms that govern flower formation.
Technician Kazuko ONGA
Tenure-track Associate Professors
Dr. Takumi HIGAKIResearch Interests: Quantitative bioimaging, cell morphogenesis, cytoskeleton and organelles
Actin filaments of plants
Actin, a protein that is ubiquitous in eukaryotes, forms actin filaments by its polymerization under physiological conditions. Actin filaments are deeply involved in cell morphological changes through formation of higher-order structures such as networks and bundles. In the case of plant cells in particular, actin filaments regulate various organelle dynamics. We aim for visible understanding of actin filament roles in cell division, cell expansion, and cell death, in which plant cell undergoes drastic changes.
Stomatal development and movement
The stomata on the plant leaf and stem surfaces is essential for plant survival because they are responsible for gaseous exchange and transpiration. The stomatal density and aperture is appropriately regulated in response to environmental cues. Using multiple approaches including biochemistry, molecular biology, live cell imaging, image analysis, and mathematical modeling, we aim for visible understanding of the multi-scale spatiotemporal control mechanism of plant stomata.
Image analysis tool development
When addressing problems in the cell biological studies described above, quantitative evaluations of cell structure and movement involving microscopic image analyses are essential. However, existing image analysis softwares are frequently insufficient. This is because the acquired image types and objectives are highly diversified in cell biology studies. For this reason, we are developing image analysis tools that would promote research progress from the standpoint of experimental cell biologists.
Technician Remi KAWAKAMI Technician Hitomi OKADA
Dr. Ruda LEEResearch Interests: Molecular engineering, molecular imaging, nanomedicine, and drug delivery
Prof. Ruda Lee, PH.D.
International Research Organization for Advanced Science and Technology (IROAST)
Kumamoto University, Japan
Ph.D., Korea University, School of Medicine (2013)
2017-present Associate Professor (Kumamoto University, Japan) 2014-2016 Postdoctral fellow (IIT, Italy) 2013-2014 Postdoctral fellow (KIST, Korea) 2009-2013 MS & Ph.D course trainee (KIST, Korea) 2008-2009 Research Assistant (KIST, Korea)
Selected peer-reviewed publications
- Lee A et al. Early diagnosis of arthritis in mice with collagen-induced arthritis, using a fluorogenic MMP 3-specific polymeric probe. Arthritis Rheum 2011
- Lee A et al. Measurement of MMP Activity in Synovial Fluid in Cases of Osteoarthritis and Acute Inflammatory Conditions of the Knee Joints Using a Fluorogenic Peptide Probe-Immobilized Diagnostic Kit. Theranostics 2012
- Lee A et al. A novel near-infrared fluorescence chemosensor for copper ion detection using click ligation and energy transfer. Chem Comm. 2013
- Lee A et al. TNF-α Gene Silencing Using Polymerized siRNA/Thiolated Glycol Chitosan Nanoparticles for Rheumatoid Arthritis. Mol Ther 2014
- Lee A et al. Spherical Polymeric Nanoconstructs for Combined Chemotherapeutic and anti-Inflammatory Therapies. Nanomedicine : NBM 2016
- Lee A et al. Dexamethasone-loaded nanoconstructs for treating and monitoring inflammation in murine colitis models. Theranostics 2017
- Lee A et al. Visualization of MMP-2 Activity Using Dual-Probe Nanoparticles to Detect Potential Metastatic Cancer Cells. Nanomaterials 2018
- Kim MW et al. Anti-EGF Receptor Aptamer-Guided Co-Delivery of Anti-Cancer siRNAs and Quantum Dots for Theranostics of Triple-Negative Breast Cancer. Theranostics 2019 (co-author)
- Ueno S et al. Development of ErbB2-Targeting Liposomes for Enhancing Drug Delivery to ErbB2-Positive Breast Cancer. Pharmaceutics 2020 (Corresponding)
- Park YI et al. pH-sensitive multi-drug liposomes targeting folate receptor β for efficient treatment of non-small cell lung cancer.Journal of Controlled Release 2021 (Corresponding)
Research in the Lee lab develops novel molecular imaging sensors and multifunction drug delivery carriers for ‘Theragnosis’ (Therapy + Diagnosis).
1. Enzyme specific activated imaging sensor based real-time in vivo imaging
Proteases are among the most studied enzyme families due to their involvement in the regulation of diverse disease processes and their potential value as biomarkers and therapeutic targets. We reported various protease target Near-infrared fluorescence (NIRF) imaging sensors and detecting pathologic processes at the cellular and molecular levels in vivo, such as cancer, arthritis, brain disorder and inflammation.
2. Active targeting drug delivery nanomaterials
Active targeted drug delivery material delivers a therapeutic and/or diagnostic agent to a targeted diseased area. Drug-loaded nanomaterials (NPs) are decorated by the peptide, aptamer, antibody for recognition by specific receptors/antigens on target cells. In this strategy, NPs can avoid non-specific biodistribution, reducing cytotoxicity and treatment dosage. It could provide patients to have chances of effective therapeutic treatment.
3. Stimuli responsive controlled drug release system
Owing to precise stimuli response, stimuli-responsive DDSs can control drug release, so as to improve the curative effects, reduce the damage of normal tissues and organs, and decrease the side effects of traditional anticancer drugs. We designed endogenous stimuli-responsive materials (pH, enzyme and redox responsive) and exogenous stimuli-responsive materials (such as light and ultrasound).
- Associate Prof. Ruda Lee - Students M2 Sho Ueno M1 Naoki Furutachi M1 Sho Tanigawa B4 Miu Goto B4 Nozomi Koga
Dr. Hiroki MATSUOResearch Interests: Ferroelectrics, Lattice defects, Domain engineering, Pulsed-laser
Ferroelectric materials have spontaneous electric polarization arising from a non-centrosymmetric crystal structure that can reversed by application of external electric field. Because of their characteristic polar structure, ferroelectric materials exhibit various functions such as piezoelectricity, pyroelectricity, electro-optic effect and anomalous photovoltaic effect, etc. Current research interest is the exploration of novel functions of the ferroelectric materials based on the following materials design strategies.
1.Ferroelectric artificial superlattice
A superlattice thin film has a periodic structure composed of thin layers of two or more materials. Because of an interfacial effect and a strong interaction between the layers, the superlattice sometimes exhibits unexpected property that is not predictable from the bulk properties of the constituting materials. The study aims to develop a ferroelectric thin-film capacitor that exhibits quite high energy density by exploiting the characteristic feature of the superlattice structure. For the fabrication of the ferroelectric superlattice, pulsed-laser deposition method with a reflection high energy electron diffraction system is used.
2.Ferroelectric photovoltaic effect
Ferroelectric materials exhibit characteristic photovoltaic responses owing to their polar crystal structure. While photovoltage generated by the conventional p-n junction of semiconductors is limited by bandgap energy of the materials, ferroelectric materials exhibit a high photovoltage exceeding the bandgap energy of them. We aim to enhance the photovoltaic response of the ferroelectric materials especially under visible light irradiation by chemical doping and by controlling ferroelectric domain structures.
3.Interaction between ferroelectric polarization and lattice defects
Charged lattice defects in the ferroelectric crystals strongly interact with the ferroelectric polarization through electrostatic and mechanical effects. The interaction enables control of the ferroelectric property by designing species, concentration, and distribution of the defects in the crystals. The goal of this study is to establish an effective approach to obtain desired ferroelectric properties by defect engineering.
Tenure-track Assistant Professor
None for now
Project Assistant Professor
Dr. Akiko NAKAMASU
Higaki LabResearch Interests: Pattern formation, plant morphogenesis, and theoretical and mathematical biology
Dr. Mizuki YAMADA
Aida LabResearch Interests: Plant morphogenesis, plant signaling
Young Faculty Members for International Joint Research
Dr. Takahiro HOSONO
Faculty of Advanced Science and TechnologyResearch Interests: Environment dynamics analysis, Environmental assessment, Hydro-environmental science, Environmental isotope science, Natural disasters
Dr. Kei Ishida
Center for Water Cycle, Marine Environment and Disaster ManagementResearch Interests: Hydrology
Dr. Mizue MUNEKATA
Advanced Thermal and Fluid Energy System Group, Division of Industrial Fundamentals, Faculty of Advanced Science and TechnologyResearch Interests: Fluid engineering
Dr. Yuta NAKASHIMA
Faculty of Advanced Science and TechnologyResearch Interests: Biomedical engineering, Biomedical devices
Dr. U Rajendra ACHARYA
Senior faculty member
Ngee Ann Polytechnic, SingaporeResearch Interests: Signal and Image processing and Artificial Intelligence
Dr. José E. ANDRADE
California Institute of Technology (Caltech),USAResearch Interests: Developing a fundamental understanding of the multiscaleand multiphysical behaviors of porous materials—everything from soils, rocks, and concrete to bone.
Behavior of granular materials like sand, snow, and even grain stored in silos.
Dr. Josep-Lluís BARONA-VILAR
Institute of History of Medicine and Science López Piñero (IHMC),
University of Valencia, SpainResearch Interests: History of science, history of medicine
Dr. Pouyan BOUKANY
Delft University of Technology,
NetherlandsResearch Interests: Living Soft Matter, complex fluids, biomicrofluidics and biomechanics
Dr. Olivier BOUTIN
Professor Deputy Director M2P2, Director Master Chemical Engineering
M2P2 Laboratory, Aix Marseille University, FranceResearch Interests: Chemical engineering, high pressure and high temperature process for waste treatment and biomass valorisation, Wet air oxidation.
Dr. Paul BOWEN
School of Metallurgy and Materials
University of Birmingham, UKResearch Interests: Characterisation, development, fracture and fatigue of alloys and composite materials (MMCs and CMCs), etc. Please see below.
Dr. Pierre BREUL
University of Clermont Auvergne, FranceResearch Interests: Soils and granular materials mechanics
Dr. Maria Jose COCERO
Chemical Engineering & Environmental Technology
The University of Valladolid, SpainResearch Interests: Development of biorefinery processes and products.
Healthy and high added value products from renewable raw materials.
Intensification of processes through the implementation of new technologies for revaluation of raw materials and waste.
Energy and fuels for the sustainable development.
Dr. Marc DE BOISSIEU
SIMaP, CNRS, Université Grenoble Alpes, FranceResearch Interests: Quasicrystals, structure, phonon and phason,
Coherent x-ray diffraction imaging,
Ge based clathrates
Dr. Patrice DELMAS
Department of Computer Science,
The University of Auckland, New ZealandResearch Interests: Image processing techniques applied to soil science, 2D/3D medical imaging, Theoretical and Applied Computer Vision at large
Dr. Martin DIENWIEBEL
Karlsruhe Institute for Technology (KIT), GermanyResearch Interests: Tribology, surface science, nanotribology
Dr. Martino DI SERIO
University of Naples Federico II, ItalyResearch Interests: Catalysis, Green Chemistry
Dr. Derek ELSWORTH
Department of Energy and Mineral Engineering and of Geosciences
The Pennsylvania State University, USAResearch Interests: Computational mechanics, rock mechanics, and in the mechanical and transport characteristics of fractured rocks
Dr. Carolina ESCOBAR
Department of Environmental Sciences
School of Environmental Sciences and Biochemistry
University of Castilla La Mancha, SpainResearch Interests: Phytopathology (Molecular knowledge of the Plant-nematode interaction and nematodes control)
Dr. Amir A. FARAJIAN
Department of Mechanical and Materials Engineering
Wright State University, USAResearch Interests: Nanoscience and nanotechnology with emphasis on computational modeling, sensors, materials for renewable energy, inelastic response, nano- and molecular-electronics, nanoelectromechanical systems, electronic and thermal quantum transports, bio-inspired nanomaterials.
Dr. Etsuko FUJITA
Brookhaven National Laboratory, USAResearch Interests: Photochemistry of transition-metal complexes, organometallic compounds, and band-gap-narrowed semiconductors; photochemical and electrochemical CO2 reduction and water splitting; small molecule activation
Dr. Tomonari FURUKAWA
Department of Mechanical and Aerospace Engineering
University of Virginia, USAResearch Interests: Robotics, autonomous systems, computational/experimental mechanics
Dr. Hamid GHANDEHARI
Director of Utah Center for Nanomedicine,
Professor of Department of Pharmaceutics and Pharmaceutical Chemistry and Bioengineering,
University of Utah, USAResearch Interests: Engineering biomaterials for delivery of bioactive agents, toxicology of engineered nanoconstructs
Dr. Olivier HAMANT
INRA, RDP, ENS Lyon, FranceResearch Interests: Plant development, mechanical signals
Dr. Christian HARDTKE
Department of Plant Molecular Biology, University of Lausanne, SwitzerlandResearch Interests: Plant development, vascular differentiation, plant hormones, peptide signalling
Dr. Jens HARTMANN
Institute for Geology, Universität Hamburg, GermanyResearch Interests: Aquatic geochemistry, global biogeochemical cycles
Dr. Yuichiro HIMEDA
Prime Senior Researcher
Carbon-based Energy Carrier Research Team, Global Zero Emission Research Center, National Institute of Advanced Industrial Science and Technology, JapanResearch Interests: CO2 utilization, Homogeneous catalyst, Hydrogen carrier
Dr. Dragos HORVATH
CNRS Research Director
Laboratory of Chemoinformatics UMR7140
University of Strasbourg, FranceResearch Interests: Chemoinformatics, Computer-aided Drug Design, Molecular Modeling, Implicit Solvent Models, Nature-Inspired Optimization Heuristics
Dr. Ryushiro KASAHARA
Department of Life Science, Fujian Agriculture and Forestry University, ChinaResearch Interests: Plant Reproduction, Seed formation
Dr. Yang KIM
Kosin University, KoreaResearch Interests: Supramolecular chemistry, chemosensor
Dr. Alexei KUZMIN
Head of Laboratory
EXAFS Spectroscopy Laboratory
Institute of Solid State Physics, University of Latvia, Riga, LatviaResearch Interests: X-ray absorption spectroscopy, computer simulations, oxide materials
Dr. Ick Chan KWON
Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, USA
Principal Research Scientist
Biomedical Research Institute, Korea Institute of Science and Technology (KIST), KoreaResearch Interests: Drug delivery system, molecular imaging, theragnosis, nanomedicine
Dr. Youn-Woo LEE
School of Chemical and Biological Engineering,
Seoul National University, KoreaResearch Interests: Supercritical Fluid Technology
Dr. Pavel LEJČEK
Institute of Physics, Academy of Sciences of the Czech Republic, Czech Republic, AND
University of Chemistry and Technology, Prague, Czech RepublicResearch Interests: Metallurgy, materials science
Dr. Viren Ivor MENEZES
Department of Aerospace Engineering,
Indian Institute of Technology Bombay, IndiaResearch Interests: Applications of shock waves and hypersonic aerothermodynamics
Dr. Matthieu MICOULAUT
Sorbonne University, FranceResearch Interests: Glasses, liquids.
Glass transition, structure of disordered materials.
Dr. Dmitri Aleks MOLODOV
Institute of Physical Metallurgy and Metal Physics,
RWTH Aachen University, GermanyResearch Interests: Characterization and control of micro-structure evolution in polycrystalline solids; Dynamic properties of interfaces in metals and alloys; Crystal plasticity
Dr. Rahul Raveendran NAIR
National Graphene Institute and School of Chemical Engineering and Analytical Science
The University of Manchester, UKResearch Interests: Materials physics, 2D materials, nanoscience and nanotechnology, 2D materials based membranes and coating, nanofluidics
Dr. Reiko ODA
CBMN UMR5248, CNRS,
University of Bordeaux, FranceResearch Interests: Colloid/surfactant chemistry, physical chemistry
Dr. Shie-Ming PENG
Distinguished Research Professor
National Taiwan University, TaiwanResearch Interests: Inorganic Chemistry; Crystallography; Nano Science.
Structure and Bonding of Transition Metal Complexes; Metal-Metal Bonds; Molecular Metal Wires; Molecular Electronics.
Dr. Ramesh Shanmughom PILLAI
Department of Molecular Biology,
University of Geneva, SwitzerlandResearch Interests: RNA biology and epigenetics
Dr. Zoran REN
Faculty of Mechanical Engineering,
University of Maribor, SloveniaResearch Interests: Advanced computation solid mechanics, cellular materials, impact and dynamics
Dr. Christian RENTENBERGER
Faculty of Physics
University of Vienna, AustriaResearch Interests: Structure and properties of nanocrystalline and amorphous materials, electron microscopy methods
Dr. Stelios RIGOPOULOS
Reader in Thermofluids
Department of Mechanical Engineering
Imperial College London, UKResearch Interests: Population balance modelling, aerosol science, fluid mechanics, reacting flows, LES/DNS, PDF methods, combustion, crystallisation, chemical kinetics, machine learning.
Dr. Shirley SHEN
Principal Research Scientist
Commonwealth Scientific and Industrial Research Organisation (CSIRO), AustraliaResearch Interests: Nanomaterials, Surfacel interphase designs and embedded functions
Dr. Atsushi URAKAWA
Delft University of Technology (TU Delft), the NetherlandsResearch Interests: Heterogeneous catalysis, in situ / operando spectroscop
Dr. Gioacchino (Cino) VIGGIANI
Solid Mechanics and Civil Engineering
Université Grenoble Alpes, FranceResearch Interests: Geomechanics
Dr. Thomas WAITZ
Associate University Professor
Faculty of Physics, University of Vienna, AustriaResearch Interests: Nanostructured materials, shape memory alloys, phase transformations, transmission electron microscopy
Dr. Andrew WHITTLE
Professor of Civil & Environmental Engineering
Massachusetts Institute of Technology (MIT), USAResearch Interests: Geotechnical, urban infrastructure
Dr. Zhenghe XU
College of Engineering,
Southern University of Science and Technology, Shenzhen, China
Department of Chemical and Materials Engineering, University of Alberta, Edmonton, CanadaResearch Interests: Engineering of nano particles and composites for bio, energy and environmental applications, etc.
Dr. Firuz ZARE
Power and Energy Group,
The University of Queensland, AustraliaResearch Interests: Power electronics and energy conversion
Visiting Associate Professors
Dr. Tomoyasu MANI
Department of Chemistry, University of Connecticut, USAResearch Interests: Electron and energy transfer, spin chemistry
Dr. Daniel P. ZITTERBART
Woods Hole Oceanographic Institution
USAResearch Interests: Marine Animal Remote Sensing
|Senior Administrator||Tomomi MAEDA|
|Staff Member||Takayuki UENO|
|Research Support Associate||Tae SATO|
|Clerical Assistant||Akiko TAJIRI|
|International Coordinator||Junko MOTOORI|