Associate Professor, Institute of Industrial Nanomaterials (IINa)
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Research in the Lee lab develops novel molecular imaging sensors and multifunction drug delivery carriers for ‘Theragnosis’ (Therapy + Diagnosis).
Proteases are among the most studied enzyme families due to their involvement in regulating diverse disease processes and their potential value as biomarkers and therapeutic targets. We reported various protease target Near-infrared fluorescence (NIRF) imaging sensors and detecting pathologic processes at the cellular and molecular levels in vivo, such as cancer, arthritis, brain disorder, and inflammation.
Active targeted drug delivery material delivers a therapeutic and diagnostic agent to a targeted diseased area. Drug-loaded nanomaterials (NPs) are decorated by the peptide, aptamer, and antibody for recognition by specific receptors/antigens on target cells. In this strategy, NPs can avoid non-specific biodistribution, reducing cytotoxicity and treatment dosage. It could provide patients to have a chance for effective treatment.
Owing to precise stimuli response, stimuli-responsive DDSs can control drug release to improve the curative effects, reduce the damage to normal tissues and organs, and decrease the side effects of traditional anticancer drugs. We designed endogenous stimuli-responsive materials (pH, enzyme, and redox responsive) and exogenous stimuli-responsive materials (such as light and ultrasound)
Ph.D., Korea University, School of Medicine (2013)
|2022-present||Associate Professor (IINa, Kumamoto University, Japan)|
|2017-2021||Associate Professor (IROAST, Kumamoto University, Japan)|
|2014-2016||Postdoctral fellow (IIT, Italy)|
|2013-2014||Postdoctral fellow (KIST, Korea)|
|2009-2013||MS & Ph.D course trainee (KIST, Korea)|
|2008-2009||Research Assistant (KIST, Korea)|
|- Associate Prof.||Ruda Lee|
|- Students||M2||Naoki Furutachi|
(Dr. Ruda LEE in the center) (Group Photo at the venue)
Ruda Lee, Nanoplatform for constructing new approaches to cancer treatment. Kangwon National University, 2022/03/30, Web.
Japan Agency for Medical Research and Development (AMED), FY 2021 Infectious Diseases and Immunology Research: U.S.-Japan Cooperative Medical Sciences Program Collaborative Awards, "Investigating DNA origami vaccine efficacy in infectious diseases", April 2021-March 2023
FY2020 Kumamoto University Support Program for enhancing Research Ability of Women Researchers (正式名：令和２年度熊本大学女性研究者研究力向上のための支援事業),"Development of stimuli responsive high drug-loading nanoparticles", 2020.