Associate Professor, Institute of Industrial Nanomaterials (IINa)
Ph.D., Korea University, School of Medicine (2013)
2022-present | Associate Professor (IINa, Kumamoto University, Japan) |
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2017-2021 | Associate Professor (IROAST, Kumamoto University, Japan) |
2014-2016 | Postdoctral fellow (IIT, Italy) |
2013-2014 | Postdoctral fellow (KIST, Korea) |
2009-2013 | MS & Ph.D course trainee (KIST, Korea) |
2008-2009 | Research Assistant (KIST, Korea) |
Research in the Lee lab develops novel molecular imaging sensors and multifunction drug delivery carriers for ‘Theragnosis’ (Therapy + Diagnosis).
Proteases are among the most studied enzyme families due to their involvement in regulating diverse disease processes and their potential value as biomarkers and therapeutic targets. We reported various protease target Near-infrared fluorescence (NIRF) imaging sensors and detecting pathologic processes at the cellular and molecular levels in vivo, such as cancer, arthritis, brain disorder, and inflammation.
Active targeted drug delivery material delivers a therapeutic and diagnostic agent to a targeted diseased area. Drug-loaded nanomaterials (NPs) are decorated by the peptide, aptamer, and antibody for recognition by specific receptors/antigens on target cells. In this strategy, NPs can avoid non-specific biodistribution, reducing cytotoxicity and treatment dosage. It could provide patients to have a chance for effective treatment.
Owing to precise stimuli response, stimuli-responsive DDSs can control drug release to improve the curative effects, reduce the damage to normal tissues and organs, and decrease the side effects of traditional anticancer drugs. We designed endogenous stimuli-responsive materials (pH, enzyme, and redox responsive) and exogenous stimuli-responsive materials (such as light and ultrasound)
- Associate Prof. | Ruda Lee | |
- Students | M2 | Naoki Furutachi |
M2 | Sho Tanigawa | |
M1 | Miu Goto | |
M1 | Nozomi Koga | |
M1 | Naoya Iwata | |
M1 | Ren Yamamoto | |
B4 | Mahiro Morita | |
B4 | Yoshito Hirata |