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RESEARCH
Novel Cancer Medical Technology Using Liquid Biopsy
Research Keyword: Liquid biopsy, Cancer, Detection, Diagnosis, Monitoring
The purpose of this research is to develop palm-sized medical devices for cancer detection, postoperative management, therapy, and drug discovery based on the signals emitted by cells and cells themselves (such as proteins and genes expressed and produced), their responses to stimuli, and the characteristics and properties of cells, such as cell morphology and new technologies to realize such devices.
Ultimately, we will integrate the various elements described above according to the purpose, and try to realize a comprehensive medical system that can consistently perform everything from early detection of cancer to identification of the primary tumor, treatment, and drug administration.
Cluster members
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CoordinatorYuta NAKASHIMA WebsiteAssociate Professor
Research Field of Bioengineering, Division of Biomedical Engineering, Faculty of Advanced Science and Technology, Kumamoto UniversityJapan -
Chengkuo LEEProfessor
National University of SingaporeSingapore -
Wataru IWASAKIChief research officer
National Institute of Advanced Industrial Science and TechnologyJapan -
Yoichi SAITO WebsiteAssistant Professor
Faculty of Advanced Science and Technology, Kumamoto UniversityJapan -
Mami AKAIKEDoctoral student
Graduate School of Science and Technology, Kumamoto UniversityJapan
Achievement
Publications
- 2023
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- Development of a Microfluidic Ion Current Measurement System for Single-Microplastic Detection
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J. Robot. Mechatron., Vol.35 No.5, pp. 1193-1202, 2023.
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- Development of Cell Micropatterning Technique Using Laser Processing of Alginate Gel
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J. Robot. Mechatron., Vol.35 No.5, pp. 1185-1192, 2023.
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- Generation of Nano/Microplastics for Immunological Assessments
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Biotribology, 33-34, 100235, 2023*This also appears in the special Issue contained from the scientific theme “Biotribology and Biomimetics” of the 7th World Tribology Congress 2022
*This is also supported by "IROAST Start-up Program for Formulation of Joint Research Hub by Crossing Departments 2021"
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- CD169+ sinus macrophages in regional lymph nodes do not predict mismatch-repair status of patients with colorectal cancer
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Cancer Medicine, 12(9), 10199-10211, 2023
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- 2022
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- Classification of PD-L1 expression in various cancers and macrophages based on immunohistocytological analysis
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Cancer Science, 113(9), 3255-3266, 2022
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- Fabrication of Three-Dimensionally Deformable Metal Structures Using Precision Electroforming
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Micromachines, 13(7), 1046 (2022)*This article belongs to the Special Issue Emerging Micro Manufacturing Technologies and Applications
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- A thermoresponsive valve to control fluid flow in microfluidic paper-based devices
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Microfluid Nanofluid, 26, 47 (2022)
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- Novel Inhibitor for Downstream Targeting of Transforming Growth Factor-β Signaling to Suppress Epithelial to Mesenchymal Transition and Cell Migration
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International Journal of Molecular Sciences, 23(9), 5047, 2022.
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- Reversible Thermo-Responsive Valve for Microfluidic Paper-Based Analytical Devices
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Micromachines, 13(5), 690, 2022
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Publications
Grants
KAKENHI (Grant-in-Aid for Challenging Research (Exploratory)), ¥ 4,900,000-, Apr. 2023 – Mar. 2025 (Principal Investigator)
KAKENHI (Grant-in-Aid for Scientific Research (B)), ¥ 3,000,000-, Apr. 2020 – Mar. 2023. (Co-Investigator)
Go-Tech (成長型中小企業等研究開発支援事業), ¥ 7,498,400-, Apr. 2023 – Mar. 2024. (Sub-Leader)
Go-Tech (成長型中小企業等研究開発支援事業), ¥ 3,092,949-, Apr. 2023 – Mar. 2024. (Co-Investigator)
JST FOREST, \ 20,000,000-, Apr. 2022 – Mar. 2025. (Principal Investigator)
KAKENHI (Grant-in-Aid for Scientific Research (C)), ¥ 600,000-, Apr. 2022 – Mar. 2025. (Co-Investigator)
KAKENHI (Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))), \ 2,500,000-, Apr. 2019 – Mar. 2025. (Co-Investigator)
Patents
光学測定器用サンプルホルダおよび光学測定器, 特許第7425428号, 2024年1月23日
中島雄太，西川昌平
出願人：国立大学法人熊本大学，西川計測株式会社
中島雄太
Activities
Nov. 25-28, 2023:
National University of Singapore, Singapore (→NEWS)
From left, Dr. Lee, Ms. Akaike, and Dr. Nakashima
- Cluster of Young Researchers
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- Ferroelectric Photovoltaics
- Next-Generation Design of Building Structures-DfX
- Low-Dimensional Molecular Electronics and Spintronics
- Development of extrachromosomal DNA control system for reprogramming drug-resistant cancer
- Development of Microbially-Aided Carbon Sequestration Technology
- Digital Plant Cell Biology
- Deep Learning for Hydrology
- Study of First-Generation Objects in the Universe with Radio Telescopes
- Separation, Synthesis, and Detection by Means of Ionic Solutes Handling
- Advanced Biomedical Evaluation System
- Environmentally Promising Processes for Medical and Skincare Nanomaterials
- Environmental Diagnosis on Earth Surface Systems
- Novel Cancer Medical Technology Using Liquid Biopsy
- Cluster of World-leading Researchers
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- Development of Nano and Supramolecular Materials
- Plant Cell and Developmental Biology
- Nano-Organics and Nano-Hybrids
- Nano-medicine and Drug Delivery System
- Nano-medicine and Theranostics
- Structure and Dynamics of Materials Using Quantum Beams and Data-Driven Sciences
- Quantification of Three Dimensional Vascular Network
- Advanced Structural Materials
- Plant Stem Cells and Regeneration
- Microstructure Analysis and Grain Boundary Engineering
- Nano-materials for Energy Applications and Environmental Protection
- Micro- and Nanomechanics of Materials Science & Biological Systems
